Current status of pan-genome analysis for pathogenic bacteria

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Biological knowledge accumulated over the decades and advances in computational methods have facilitated the implementation of pan-genome analysis that aims at better understanding of genotype-phenotype associations of a specific group of organisms. Pan-genome analysis has been shown to be an effective approach to better understand a clade of pathogenic bacteria because it helps developing various and tailored therapeutic strategies on the basis of their biological similarities and differences. Here, we review recent progress in the pan-genome analysis of pathogenic bacteria. In particular, we focus on computational tools that allow streamlined pan-genome analysis. Also, various applications of pan-genome analysis including those relevant to devising strategies for the prevention and treatment of pathogenic bacteria are reviewed.
Publisher
CURRENT BIOLOGY LTD
Issue Date
2020-06
Language
English
Article Type
Review
Citation

CURRENT OPINION IN BIOTECHNOLOGY, v.63, pp.54 - 62

ISSN
0958-1669
DOI
10.1016/j.copbio.2019.12.001
URI
http://hdl.handle.net/10203/271773
Appears in Collection
CBE-Journal Papers(저널논문)
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