This paper reports microfluidic resonators with two independent channels integrated for simultaneous measurements of different or same liquid analytes, for the first time. Such a unique design intrinsically enables independent access of each integrated fluidic channel. Therefore, fast sample exchange and simultaneous loading of two different liquids can be guaranteed. Dual channel microfluidic resonators mounted on the custom vacuum clamp are thoroughly characterized with a laser Doppler vibrometer. One of the two channels would be loaded with functional materials to measure liquid properties at modulated conditions.