3차원 회절광 현미경을 이용하여 발견된 골수이형성증후군 환자의 특이한 변형적혈구 1예 Unique Red Blood Cell Morphology Detected in a Patient with Myelodysplastic Syndrome by Three-dimensional Refractive Index Tomography

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The three-dimensional (3-D) shape of erythrocytes is strongly associated with various diseases. However, conventional optical imaging approaches with Wright's staining only provide information on two-dimensional morphology. Here, we employed optical diffraction tomography (ODT), a label-free 3-D quantitative phase imaging technique, and observed uniquely shaped red blood cells (RBCs) in the peripheral blood of a patient diagnosed with myelodysplastic syndrome. Peripheral blood samples were collected when the patient visited our hospital for his two out-patient follow-ups in May 2018. The 3-D tomograms of randomly chosen RBCs were reconstructed using a commercial ODT setup. From the reconstructed 3-D RBCs, 37.5% and 32.8% of RBCs demonstrated cup-like shapes at the first and the second out-patient follow-up, respectively. Even though this is a single case report, the finding is novel and can be a potential dyserythropoietic feature found in peripheral blood.
Publisher
대한진단검사의학회
Issue Date
2019-07
Language
English
Citation

Laboratory Medicine Online, v.9, no.3, pp.185 - 188

ISSN
2093-6338
DOI
10.3343/lmo.2019.9.3.185
URI
http://hdl.handle.net/10203/271292
Appears in Collection
PH-Journal Papers(저널논문)
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