In this paper, a Mixed Integer Linear Programming(MILP) approach for solving optimal Weapon-Target Assignment(WTA) problem of multiple dissimilar Closed-In Weapon Systems (CIWS) is proposed. Generally, WTA problems are formulated in nonlinear mixed integer optimization form, which often requires impractical exhaustive search to optimize. However, transforming the problem into a structured MILP problem enables global optimization with an acceptable computational load. The problem of interest considers defense against several threats approaching the asset from various directions, with different time of arrival. Moreover, we consider multiple dissimilar CIWSs defending the asset. We derive a MILP form of the given nonlinear WTA problem. The formulated MILP problem is implemented with a commercial optimizer, and the optimization result is proposed.