On-chip label-free biosensing based on active whispering gallery mode resonators pumped by a light-emitting diode

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Biosensing based on whispering-gallery mode (WGM) resonators has been continuously studied with great attention due to its excellent sensitivity guaranteeing the label-free detection. However, its practical impact is insignificant to date despite notable achievements in academic research. Here, we demonstrate a novel practical platform of on-chip WGM sensors integrated with microfluidic channels. By placing silicon nanoclusters as a stable active compound in micro-resonators, the sensor chip can be operated with a remote pump and readout, which simplifies the chip integration and connection to the external setup. In addition, silicon nanoclusters having large absorption cross-section over broad wavelength range allow active sensing for the first time with an LED pump in a top-illumination scheme which significantly reduces the complexity and cost of the measurement setup. The nano-slot structure of 25 nm gap width is embedded in the resonator where the target bio-molecules are selectively detected with the sensitivity enhanced by strongly confined mode-field. The sensitivity confirmed by real-time measurements for the streptavidin-biotin complex is 0.012 nm/nM, improved over 20 times larger than the previously reported WGM sensors with remote readout. (C) 2019 Optical Society of America under the terms of the OSA Open Access Publishing Agreement
Publisher
OPTICAL SOC AMER
Issue Date
2019-11
Language
English
Article Type
Article
Citation

OPTICS EXPRESS, v.27, no.23, pp.34406 - 34416

ISSN
1094-4087
DOI
10.1364/OE.27.034405
URI
http://hdl.handle.net/10203/268890
Appears in Collection
NT-Journal Papers(저널논문)
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