Emulating endothelial dysfunction by implementing an early atherosclerotic microenvironment within a microfluidic chip

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Recent studies on endothelial dysfunction in relation to vascular diseases including atherosclerosis have highlighted the key contribution of the microenvironment of endothelial cells (ECs). By mimicking the microenvironment of early atherosclerotic lesions, here, we replicate the pathophysiological phenotype and function of ECs within microchannels. Considering the elevated deposition of fibronectin (FN) in early atherosclerotic plaques and the close correlation between the vascular stiffness and the progression of atherosclerosis, we utilized FN coated hydrogels with increased stiffness for endothelial substrates within the microchannels. As a result, we demonstrated that endothelial integrity on FN coated microchannels is likely to be undermined exhibiting a random orientation in response to the applied fluid flow, notable disruption of vascular endothelial cadherins (VE-cadherins), and higher endothelial permeability as opposed to that on microchannels coated with collagen (CL), the atheroresistant vascular model.
Publisher
ROYAL SOC CHEMISTRY
Issue Date
2019-11
Language
English
Article Type
Article
Citation

LAB ON A CHIP, v.19, no.21, pp.3664 - 3677

ISSN
1473-0197
DOI
10.1039/c9lc00352e
URI
http://hdl.handle.net/10203/268849
Appears in Collection
ME-Journal Papers(저널논문)
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