A Gallium-based Chiral Solvating Agent Enables the Use of H-1 NMR Spectroscopy to Differentiate Chiral Alcohols

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In situ, direct H-1 NMR chiral analysis by using chiral solvating agents is a convenient and efficient analytical technique. Here we developed a Ga-based chiral anionic metal complex for H-1 NMR chiral analysis of alcohols. Utilizing the optimal pK(a) value, the Ga complex was able to differentiate H-1 NMR signals of each (R)- and (S)-enantiomer of alcohols, measured at room temperature. This direct H-1 NMR chiral analysis of alcohols was used to rapidly determine enantiomeric excess and conversion in a kinetic resolution and an asymmetric synthesis.
Publisher
CELL PRESS
Issue Date
2019-09
Language
English
Article Type
Article
Citation

ISCIENCE, v.19, pp.425 - +

ISSN
2589-0042
DOI
10.1016/j.isci.2019.07.051
URI
http://hdl.handle.net/10203/268453
Appears in Collection
CH-Journal Papers(저널논문)
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