DC Field | Value | Language |
---|---|---|
dc.contributor.author | Han, Ji Won | ko |
dc.contributor.author | Sung, Pil Soo | ko |
dc.contributor.author | Kim, Kyung Hwan | ko |
dc.contributor.author | Hong, Seon-Hui | ko |
dc.contributor.author | Shin, Eui-Cheol | ko |
dc.contributor.author | Song, Myeong Jun | ko |
dc.contributor.author | Park, Su-Hyung | ko |
dc.date.accessioned | 2019-11-04T06:20:11Z | - |
dc.date.available | 2019-11-04T06:20:11Z | - |
dc.date.created | 2019-11-04 | - |
dc.date.created | 2019-11-04 | - |
dc.date.issued | 2019-10 | - |
dc.identifier.citation | JOURNAL OF INFECTIOUS DISEASES, v.220, no.8, pp.1290 - 1301 | - |
dc.identifier.issn | 0022-1899 | - |
dc.identifier.uri | http://hdl.handle.net/10203/268199 | - |
dc.description.abstract | Background. Direct-acting antiviral (DAA) agents can successfully treat chronic hepatitis C virus (HCV) infection. However, the ex vivo HCV-specific T-cell function following viral clearance remains unknown. Methods. We investigated functional alterations and phenotypic changes in ex vivo HCV-specific CD8(+) T cells with a longitudinal analysis of 41 patients with chronic HCV infection who were undergoing DAA treatment. Results. A patient subset exhibited a significantly increased T-cell response (mainly CD8(+) T cells) at week 4 of treatment. However, this increased T-cell response diminished in later weeks. Relative to pretreatment levels, the ex vivo HCV-specific CD8+ T-cell frequency decreased at 12 weeks after the end of treatment, along with a decreased antigen-experienced CD8(+) T-cell population. DAA treatment increased the proliferative capacity of HCV-specific CD8(+) T cells, but this change was not correlated with ex vivo function. Patients experiencing viral breakthrough or relapse exhibited defective restoration of T-cell function. Conclusion. Our present results indicated that DAA-mediated viral clearance only transiently restored ex vivo T-cell function, suggesting a need to enhance T-cell function in DAA-treated patients. | - |
dc.language | English | - |
dc.publisher | OXFORD UNIV PRESS INC | - |
dc.title | Dynamic Changes in Ex Vivo T-Cell Function After Viral Clearance in Chronic HCV Infection | - |
dc.type | Article | - |
dc.identifier.wosid | 000490988000008 | - |
dc.identifier.scopusid | 2-s2.0-85072234675 | - |
dc.type.rims | ART | - |
dc.citation.volume | 220 | - |
dc.citation.issue | 8 | - |
dc.citation.beginningpage | 1290 | - |
dc.citation.endingpage | 1301 | - |
dc.citation.publicationname | JOURNAL OF INFECTIOUS DISEASES | - |
dc.identifier.doi | 10.1093/infdis/jiz291 | - |
dc.contributor.localauthor | Shin, Eui-Cheol | - |
dc.contributor.localauthor | Park, Su-Hyung | - |
dc.contributor.nonIdAuthor | Song, Myeong Jun | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | HCV-specific T cell | - |
dc.subject.keywordAuthor | ex vivo function | - |
dc.subject.keywordAuthor | DAA | - |
dc.subject.keywordPlus | HEPATITIS-C VIRUS | - |
dc.subject.keywordPlus | SUSTAINED VIROLOGICAL RESPONSE | - |
dc.subject.keywordPlus | INTERFERON-FREE THERAPY | - |
dc.subject.keywordPlus | LYMPHOCYTE RESPONSES | - |
dc.subject.keywordPlus | IMMUNE-RESPONSES | - |
dc.subject.keywordPlus | LATE RELAPSE | - |
dc.subject.keywordPlus | RESTORATION | - |
dc.subject.keywordPlus | REINFECTION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | SUBSETS | - |
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