Exogenous Interleukin-33 Contributes to Protective Immunity via Cytotoxic T-Cell Priming against Mucosal Influenza Viral Infection

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Influenza is an infectious respiratory illness caused by the influenza virus. Though vaccines against influenza exist, they have limited efficacy. To additionally develop effective treatments, there is a need to study the mechanisms of host defenses from influenza viral infections. To date, the mechanism by which interleukin (IL)-33 modulates the antiviral immune response post-influenza infection is unclear. In this study, we demonstrate that exogenous IL-33 enhanced antiviral protection against influenza virus infection. Exogenous IL-33 induced the recruitment of dendritic cells, increased the secretion of pro-inflammatory cytokine IL-12, and promoted cytotoxic T-cell responses in the local microenvironment. Thus, our findings suggest a role of exogenous IL-33 in the antiviral immune response against influenza infection.
Publisher
MDPI
Issue Date
2019-09
Language
English
Article Type
Article
Citation

VIRUSES-BASEL, v.11, no.9

ISSN
1999-4915
DOI
10.3390/v11090840
URI
http://hdl.handle.net/10203/268057
Appears in Collection
MSE-Journal Papers(저널논문)
Files in This Item
viruses-11-00840 (1).pdf(3.15 MB)Download
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