Successful Treatment of Fulminant Hepatitis due to Varicella Zoster Virus using Immunoglobutin in a Kidney Transplant Patient

Cited 0 time in webofscience Cited 0 time in scopus
  • Hit : 89
  • Download : 0
The clinical benefit of adjuvant intravenous immunoglobulin (WIG) therapy is controversial in immunocompromised patients with severe varicella. A twenty-one-year-old woman who had received a kidney transplant one year earlier presented with fever and generalized rash for 5 days. Initial immunoglobulin M (IgM) and IgG for varicella zoster virus (VZV) were negative; however, the patient was diagnosed with varicella with fulminant hepatitis because VZV-specific PCR from skin vesicles and blood was positive. The patient received intravenous acyclovir and 5-day IVIG. The decline of plasma viral load was steeper (beta coefficient-0.446) during WIG therapy than after the therapy (beta coefficient -0.123) (P= 0.04), while VZV glycoprotein IgG titers and VZV-specific T cell responses were not detected during the 5-day WIG therapy. The patient improved without any complications. This case provides an experimental evidence that adjuvant IVIG can significantly reduce viral load in immunocompromised patients with severe varicella.
Publisher
KOREAN SOC CHEMOTHERAPY
Issue Date
2019-09
Language
English
Article Type
Article
Citation

INFECTION AND CHEMOTHERAPY, v.51, no.3, pp.310 - 314

ISSN
2093-2340
DOI
10.3947/ic.2019.51.3.310
URI
http://hdl.handle.net/10203/268023
Appears in Collection
MSE-Journal Papers(저널논문)
Files in This Item
There are no files associated with this item.

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0