Strategic Approach to the Metamorphosis of gamma-Lactones to NH gamma-Lactams via Reductive Cleavage and C-H Amidation

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A new approach has elaborated on the conversion of gamma-lactones to the corresponding NH gamma-lactams that can serve as gamma-lactone bioisosteres. This approach consists of reductive C-O cleavage and an Ir-catalyzed C-H amidation, offering a powerful synthetic tool for accessing a wide range of valuable NH gamma-lactam building blocks starting from gamma-lactones. The synthetic utility was further demonstrated by the late-stage transformation of complex bioactive molecules and the asymmetric transformation.
Publisher
AMER CHEMICAL SOC
Issue Date
2019-08
Language
English
Article Type
Article
Citation

ORGANIC LETTERS, v.21, no.17, pp.7099 - 7103

ISSN
1523-7060
DOI
10.1021/acs.orglett.9b02673
URI
http://hdl.handle.net/10203/267702
Appears in Collection
CH-Journal Papers(저널논문)
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