Studies on site-selective catalytic reactions for efficient synthesis of biologically privileged scaffolds = 위치선택적 촉매 반응을 통한 생리활성 골격체의 효율적인 합성에 대한 연구

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dc.contributor.advisorHong, Sungwoo-
dc.contributor.advisor홍승우-
dc.contributor.authorKang, Dahye-
dc.date.accessioned2019-08-25T02:51:27Z-
dc.date.available2019-08-25T02:51:27Z-
dc.date.issued2019-
dc.identifier.urihttp://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=842530&flag=dissertationen_US
dc.identifier.urihttp://hdl.handle.net/10203/265524-
dc.description학위논문(박사) - 한국과학기술원 : 화학과, 2019.2,[ii, 88 p. :]-
dc.description.abstractDeveloping efficient strategies for the synthesis of biologically active compounds is indisputably the most important topic in organic chemistry. This thesis describes experimental and computational studies on the site-selective catalytic reactions to enable efficient synthesis of functionalized quinolones, phosphorus-containing amino acid derivatives, and valuable cyclic compounds. Divergent C–C bond formation reactions of quinolones have been achieved by site-selective C–H activation using directing groups. Regiodivergent ring-opening cross-coupling of vinyl aziridines with phosphorus nucleophiles has been developed for the facile and efficient synthesis of enantioenriched phosphorus-containing amino acid derivatives. Moreover, synthetic methodologies involving C–H activation have been developed for construction of privileged ring systems including benzazepines, carbazoles, and lactones. Mechanistic investigations using density functional theory were also conducted to elucidate the reaction mechanism.-
dc.languageeng-
dc.publisher한국과학기술원-
dc.subjectcatalysis▼asite-selectivity▼aquinolone▼aaziridine▼aamino acid▼acyclic compound▼adensity functional theory-
dc.subject촉매 반응▼a위치선택성▼a퀴놀론▼a아지리딘▼a아미노산▼a고리화합물▼a밀도범함수-
dc.titleStudies on site-selective catalytic reactions for efficient synthesis of biologically privileged scaffolds = 위치선택적 촉매 반응을 통한 생리활성 골격체의 효율적인 합성에 대한 연구-
dc.typeThesis(Ph.D)-
dc.identifier.CNRN325007-
dc.description.department한국과학기술원 :화학과,-
dc.contributor.alternativeauthor강다혜-
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CH-Theses_Ph.D.(박사논문)
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