Differential coding of reward and movement information in the dorsomedial striatal direct and indirect pathways = 배내측 선조체 직접/간접 회로의 보상과 운동 정보 부호화에 대한 연구

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The direct and indirect pathways of the basal ganglia have long been thought to mediate behavioral promotion and inhibition, respectively. However, this classic dichotomous model has been recently challenged. To better understand neural processes underlying rewardbased learning and movement control, I recorded from direct (dSPNs) and indirect (iSPNs) pathway spiny projection neurons in the dorsomedial striatum of D1-Cre and D2-Cre mice performing a probabilistic Pavlovian conditioning task. dSPNs tend to increase activity while iSPNs decrease activity as a function of reward value, suggesting the striatum represents value in the relative activity levels of dSPNs versus iSPNs. Lick offset-related activity increase is largely dSPN selective, suggesting dSPN involvement in suppressing ongoing licking behavior. Rapid responses to negative outcome and previous reward-related responses are more frequent among iSPNs than dSPNs, suggesting stronger contributions of iSPNs to outcome-dependent behavioral adjustment. These findings provide new insights into striatal neural circuit operations.
Advisors
Jung, Min Whanresearcher정민환researcherJeong, Bum Seokresearcher정범석researcher
Description
한국과학기술원 :의과학대학원,
Publisher
한국과학기술원
Issue Date
2019
Identifier
325007
Language
eng
Description

학위논문(박사) - 한국과학기술원 : 의과학대학원, 2019.2,[v, 58 p. :]

Keywords

basal ganglia▼adorsomedial striatum▼adirect pathway▼aindirect pathway▼areward prediction error▼aoptogenetics▼amedium spiny neurons▼aD1 receptor▼aD2 receptor; 기저핵▼a배내측선조체▼a직접회로▼a간접회로▼a보상예측오류▼a광유전학▼a중간가시세포▼aD1 수용체▼aD2 수용체

URI
http://hdl.handle.net/10203/265101
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=842195&flag=dissertation
Appears in Collection
MSE-Theses_Ph.D.(박사논문)
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