Flexible wrapping optoelectronic devices for large area optogenetic analysis of mouse cortex쥐 뇌 피질의 대면적 광유전학 분석을 위한 유연 랩핑 광전자소자

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Cutting edge biomedical tools employ flexible optoelectronic devices combined with optogenetic mouse models providing high spatiotemporal modulation of specific brain activity. However, most applications were limited to activation of only one functional region using blue-light drivable channelrhodopsin. This thesis illustrates AlGaInP vertical light-emitting diodes (VLEDs) on flexible substrate for excitation of mouse motor cortex. Cell-sized chips effectively compress the conductive balls dispersed in anisotropic conductive film (ACF) resulting red-light emission with high optical power density. Selective operation of pulsed red-light from cell-sized flexible VLEDs (cf-VLEDs) induce mouse body movements and synchronized electromyogram (EMG) signals. Expression of chrimson, red-shifted channelrhodopsin, enables red-light excitation of detailed functional area of motor cortex. In addition, flexible electrocorticography (ECoG) electrode and its new insertion method beneath the skull facilitate large area neural signal analysis of mouse cortex in freely moving mice.
Advisors
Lee, Keon Jaeresearcher이건재researcher
Description
한국과학기술원 :신소재공학과,
Publisher
한국과학기술원
Issue Date
2017
Identifier
325007
Language
eng
Description

학위논문(박사) - 한국과학기술원 : 신소재공학과, 2017.2,[viii, 61 p. :]

Keywords

Optogenetics▼aflexible electrode▼aflexible light-emitting diode▼amotor cortex▼aelectrocorticography; 광유전학▼a유연전극▼a유연발광다이오드▼a운동피질▼a피질뇌파도

URI
http://hdl.handle.net/10203/265008
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=866962&flag=dissertation
Appears in Collection
MS-Theses_Ph.D.(박사논문)
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