Engineering the physicochemical properties of neural cells microenvironment to regulate neuronal growth and differentiation = 신경 성장과 분화 조절을 위한 신경계 세포 미세환경의 물리화학적 특성 엔지니어링

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Neural cells such as neurons and neural stem cells have recently emerged as critical candidates for cell therapy for diverse serious neurodegenerative diseases. However, these still have some limitations including unstable and insufficient cell growth and low differentiation efficiency. Therefore, regulating neural cell behaviors is important issue. In this thesis, we engineer physicochemical surface properties for cellular contact by controlling the functionalities of polymeric surface, dimension of nano-patterns, and mechanical properties and ligands of hydrogel, to regulate the neuronal cell growth and fate commitment of neural stem cells. In addition, we reveal the biomolecular mechanism how the cells process the diverse cues from these materials to their cellular behaviors.
Advisors
Im, Sung Gapresearcher임성갑researcher
Description
한국과학기술원 :생명화학공학과,
Publisher
한국과학기술원
Issue Date
2019
Identifier
325007
Language
eng
Description

학위논문(박사) - 한국과학기술원 : 생명화학공학과, 2019.2,[viii, 121 p. :]

Keywords

neuron▼aneural stem cells (NSCs)▼abiomaterials▼aneural differentiation▼amechanotransduction; 뉴런▼a신경줄기세포▼a생체재료▼a신경분화▼a세포역학신호변환

URI
http://hdl.handle.net/10203/264907
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=842130&flag=dissertation
Appears in Collection
CBE-Theses_Ph.D.(박사논문)
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