DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | Kim, Eunjoon | - |
dc.contributor.advisor | 김은준 | - |
dc.contributor.author | Kim, Ryunhee | - |
dc.date.accessioned | 2019-08-22T02:43:27Z | - |
dc.date.available | 2019-08-22T02:43:27Z | - |
dc.date.issued | 2019 | - |
dc.identifier.uri | http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=842108&flag=dissertation | en_US |
dc.identifier.uri | http://hdl.handle.net/10203/264770 | - |
dc.description | 학위논문(박사) - 한국과학기술원 : 생명과학과, 2019.2,[ⅵ, 82 p. :] | - |
dc.description.abstract | Shank2 is an excitatory postsynaptic scaffolding protein implicated in synapse regulation as well as psychiatric disorders including autism spectrum disorders. Conventional Shank2-mutant ($Shank2^{–/–}$) mice display several autistic-like behaviors, including social deficits, repetitive behaviors, hyperactivity, and anxiety-like behaviors. However, cell type-specific contributions to these behaviors have remained largely unclear. Here we deleted Shank2 in specific cell types, and found that male mice lacking Shank2 in excitatory neurons (CaMKII-Cre | - |
dc.description.abstract | $Shank2^{fl/fl}$) show social-interaction deficits and mild social-communication deficits, hyperactivity, and anxiety-like behaviors. Distinctly, male mice lacking Shank2 in GABAergic inhibitory neurons (Viaat-Cre | - |
dc.description.abstract | $Shank2^{fl/fl}$) display social-communication deficits, repetitive self-grooming, and mild hyperactivity. These behavioral changes were associated with distinct changes in hippocampal and striatal synaptic transmission in the two mouse lines. These results indicate that cell type-specific deletions of Shank2 in mice lead to differential synaptic and behavioral abnormalities. | - |
dc.language | eng | - |
dc.publisher | 한국과학기술원 | - |
dc.subject | autism▼acell type▼aexcitatory▼ainhibitory▼aShank2▼asynapse | - |
dc.subject | 자폐▼a세포 유형▼a흥분성▼a억제성▼aShank2▼a시냅스 | - |
dc.title | Distinct roles of cell-type specific Shank2 expression in the regulation of synapse function and mouse behavior | - |
dc.title.alternative | 세포 특이적 Shank2 단백질 발현이 시냅스 기능 및 생쥐 행동에 미치는 영향 연구 | - |
dc.type | Thesis(Ph.D) | - |
dc.identifier.CNRN | 325007 | - |
dc.description.department | 한국과학기술원 :생명과학과, | - |
dc.contributor.alternativeauthor | 김륜희 | - |
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