Meningeal lymphatic vessels at the skull base drain cerebrospinal fluid

Cited 86 time in webofscience Cited 0 time in scopus
  • Hit : 362
  • Download : 0
DC FieldValueLanguage
dc.contributor.authorAhn, Ji Hoonko
dc.contributor.authorCho, Hyunsooko
dc.contributor.authorKim, Jun-Heeko
dc.contributor.authorKim, Shin Heunko
dc.contributor.authorHam, Je-Seokko
dc.contributor.authorPark, Intaeko
dc.contributor.authorSuh, Sang Heonko
dc.contributor.authorHong, Seon Pyoko
dc.contributor.authorSong, Joo-Hyeko
dc.contributor.authorHong, Young-Kwonko
dc.contributor.authorJeong, Yongko
dc.contributor.authorPark, Sung-Hongko
dc.contributor.authorKoh, Gou Youngko
dc.date.accessioned2019-08-19T11:20:18Z-
dc.date.available2019-08-19T11:20:18Z-
dc.date.created2019-08-05-
dc.date.created2019-08-05-
dc.date.issued2019-08-
dc.identifier.citationNATURE, v.572, no.7767, pp.62 - 66-
dc.identifier.issn0028-0836-
dc.identifier.urihttp://hdl.handle.net/10203/264300-
dc.description.abstractRecent work has shown that meningeal lymphatic vessels (mLVs), mainly in the dorsal part of the skull, are involved in the clearance of cerebrospinal fluid (CSF), but the precise route of CSF drainage is still unknown. Here we reveal the importance of mLVs in the basal part of the skull for this process by visualizing their distinct anatomical location and characterizing their specialized morphological features, which facilitate the uptake and drainage of CSF. Unlike dorsal mLVs, basal mLVs have lymphatic valves and capillaries located adjacent to the subarachnoid space in mice. We also show that basal mLVs are hotspots for the clearance of CSF macromolecules and that both mLV integrity and CSF drainage are impaired with ageing. Our findings should increase the understanding of how mLVs contribute to the neuropathophysiological processes that are associated with ageing.-
dc.languageEnglish-
dc.publisherNATURE PUBLISHING GROUP-
dc.titleMeningeal lymphatic vessels at the skull base drain cerebrospinal fluid-
dc.typeArticle-
dc.identifier.wosid000478017900036-
dc.identifier.scopusid2-s2.0-85069677374-
dc.type.rimsART-
dc.citation.volume572-
dc.citation.issue7767-
dc.citation.beginningpage62-
dc.citation.endingpage66-
dc.citation.publicationnameNATURE-
dc.identifier.doi10.1038/s41586-019-1419-5-
dc.contributor.localauthorJeong, Yong-
dc.contributor.localauthorPark, Sung-Hong-
dc.contributor.localauthorKoh, Gou Young-
dc.contributor.nonIdAuthorCho, Hyunsoo-
dc.contributor.nonIdAuthorKim, Jun-Hee-
dc.contributor.nonIdAuthorHam, Je-Seok-
dc.contributor.nonIdAuthorPark, Intae-
dc.contributor.nonIdAuthorHong, Seon Pyo-
dc.contributor.nonIdAuthorSong, Joo-Hye-
dc.contributor.nonIdAuthorHong, Young-Kwon-
dc.description.isOpenAccessN-
dc.type.journalArticleArticle-
dc.subject.keywordPlusSYSTEM-
dc.subject.keywordPlusFOXC2-
Appears in Collection
BiS-Journal Papers(저널논문)MSE-Journal Papers(저널논문)
Files in This Item
There are no files associated with this item.
This item is cited by other documents in WoS
⊙ Detail Information in WoSⓡ Click to see webofscience_button
⊙ Cited 86 items in WoS Click to see citing articles in records_button

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0