SynGO: an evidence-based, expert-curated resource for synapse function and gene enrichment studies

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dc.contributor.authorKoopmans, Frankko
dc.contributor.authorvan Nierop, Pimko
dc.contributor.authorAndres-Alonso, Mariako
dc.contributor.authorBymes, Andreako
dc.contributor.authorCijsouw, Tonyko
dc.contributor.authorCoba, Marcelo P.ko
dc.contributor.authorCornelisse, L. Nielsko
dc.contributor.authorFarrell, Ryan J.ko
dc.contributor.authorGoldschmidt, Hana L.ko
dc.contributor.authorHowrigan, Daniel P.ko
dc.contributor.authorHussain, Natasha K.ko
dc.contributor.authorImig, Cordeliako
dc.contributor.authorde Jong, Arthur P. H.ko
dc.contributor.authorJung, Hwajinko
dc.contributor.authorKohansalnodehi, Mandokhtko
dc.contributor.authorKramarz, Barbarako
dc.contributor.authorLipstein, Noako
dc.contributor.authorLovering, Ruth C.ko
dc.contributor.authorMacGillavry, Haroldko
dc.contributor.authorMariano, Vittoriako
dc.contributor.authorMi, Huaiyuko
dc.contributor.authorNinov, Momchilko
dc.contributor.authorOsumi-Sutherland, Davidko
dc.contributor.authorPielot, Rainerko
dc.contributor.authorSmalla, Karl-Heinzko
dc.contributor.authorTang, Haimingko
dc.contributor.authorTashman, Katherineko
dc.contributor.authorToonen, Ruud F. G.ko
dc.contributor.authorVerpelli, Chiarako
dc.contributor.authorReig-Viader, Ritako
dc.contributor.authorWatanabe, Kyokoko
dc.contributor.authorvan Weering, Janko
dc.contributor.authorAchsel, Tilmannko
dc.contributor.authorAshrafi, Ghazalehko
dc.contributor.authorAsi, Nimrako
dc.contributor.authorBrown, Tyler C.ko
dc.contributor.authorDe Camilli, Pietroko
dc.contributor.authorFeuermann, Marcko
dc.contributor.authorFoulger, Rebecca E.ko
dc.contributor.authorGaudet, Pascaleko
dc.contributor.authorJoglekar, Anoushkako
dc.contributor.authorKanellopoulos, Alexandrosko
dc.contributor.authorMalenka, Robertko
dc.contributor.authorNicoll, Roger A.ko
dc.contributor.authorPulido, Camilako
dc.contributor.authorde Juan-Sanz, Jaimeko
dc.contributor.authorSheng, Morganko
dc.contributor.authorSudhof, Thomas C.ko
dc.contributor.authorTilgner, Hagen U.ko
dc.contributor.authorBagni, Claudiako
dc.contributor.authorBayes, Alexko
dc.contributor.authorBiederer, Thomasko
dc.contributor.authorBrose, Nilsko
dc.contributor.authorChua, John Jia Enko
dc.contributor.authorDieterich, Daniela C.ko
dc.contributor.authorGundelfinger, Eckart D.ko
dc.contributor.authorHoogenraad, Casperko
dc.contributor.authorHuganir, Richard L.ko
dc.contributor.authorJahn, Reinhardko
dc.contributor.authorKaeser, Pascal S.ko
dc.contributor.authorKim, Eunjoonko
dc.contributor.authorKreutz, Michael R.ko
dc.contributor.authorMcPherson, Peter S.ko
dc.contributor.authorNeale, Ben M.ko
dc.contributor.authorO'Connor, Vincentko
dc.contributor.authorPosthuma, Danielleko
dc.contributor.authorRyan, Timothy A.ko
dc.contributor.authorSala, Carloko
dc.contributor.authorFeng, Guopingko
dc.contributor.authorHyman, Steven E.ko
dc.contributor.authorThomas, Paul D.ko
dc.contributor.authorSmit, August B.ko
dc.contributor.authorVerhage, Matthijsko
dc.date.accessioned2019-08-05T06:20:49Z-
dc.date.available2019-08-05T06:20:49Z-
dc.date.created2019-08-05-
dc.date.created2019-08-05-
dc.date.issued2019-07-
dc.identifier.citationNEURON, v.103, no.2, pp.217 - +-
dc.identifier.issn0896-6273-
dc.identifier.urihttp://hdl.handle.net/10203/263992-
dc.description.abstractSynapses are fundamental information-processing units of the brain, and synaptic dysregulation is central to many brain disorders ("synaptopathies''). However, systematic annotation of synaptic genes and ontology of synaptic processes are currently lacking. We established SynGO, an interactive knowledge base that accumulates available research about synapse biology using Gene Ontology (GO) annotations to novel ontology terms: 87 synaptic locations and 179 synaptic processes. SynGO annotations are exclusively based on published, expert-curated evidence. Using 2,922 annotations for 1,112 genes, we show that synaptic genes are exceptionally well conserved and less tolerant to mutations than other genes. Many SynGO terms are significantly overrepresented among gene variations associated with intelligence, educational attainment, ADHD, autism, and bipolar disorder and among de novo variants associated with neurodevelopmental disorders, including schizophrenia. SynGO is a public, universal reference for synapse research and an online analysis platform for interpretation of large-scale -omics data (https://syngoportal.org and http://geneontology.org).-
dc.languageEnglish-
dc.publisherCELL PRESS-
dc.titleSynGO: an evidence-based, expert-curated resource for synapse function and gene enrichment studies-
dc.typeArticle-
dc.identifier.wosid000475776000010-
dc.identifier.scopusid2-s2.0-85068734308-
dc.type.rimsART-
dc.citation.volume103-
dc.citation.issue2-
dc.citation.beginningpage217-
dc.citation.endingpage+-
dc.citation.publicationnameNEURON-
dc.identifier.doi10.1016/j.neuron.2019.05.002-
dc.contributor.localauthorKim, Eunjoon-
dc.contributor.nonIdAuthorKoopmans, Frank-
dc.contributor.nonIdAuthorvan Nierop, Pim-
dc.contributor.nonIdAuthorAndres-Alonso, Maria-
dc.contributor.nonIdAuthorBymes, Andrea-
dc.contributor.nonIdAuthorCijsouw, Tony-
dc.contributor.nonIdAuthorCoba, Marcelo P.-
dc.contributor.nonIdAuthorCornelisse, L. Niels-
dc.contributor.nonIdAuthorFarrell, Ryan J.-
dc.contributor.nonIdAuthorGoldschmidt, Hana L.-
dc.contributor.nonIdAuthorHowrigan, Daniel P.-
dc.contributor.nonIdAuthorHussain, Natasha K.-
dc.contributor.nonIdAuthorImig, Cordelia-
dc.contributor.nonIdAuthorde Jong, Arthur P. H.-
dc.contributor.nonIdAuthorJung, Hwajin-
dc.contributor.nonIdAuthorKohansalnodehi, Mandokht-
dc.contributor.nonIdAuthorKramarz, Barbara-
dc.contributor.nonIdAuthorLipstein, Noa-
dc.contributor.nonIdAuthorLovering, Ruth C.-
dc.contributor.nonIdAuthorMacGillavry, Harold-
dc.contributor.nonIdAuthorMariano, Vittoria-
dc.contributor.nonIdAuthorMi, Huaiyu-
dc.contributor.nonIdAuthorNinov, Momchil-
dc.contributor.nonIdAuthorOsumi-Sutherland, David-
dc.contributor.nonIdAuthorPielot, Rainer-
dc.contributor.nonIdAuthorSmalla, Karl-Heinz-
dc.contributor.nonIdAuthorTang, Haiming-
dc.contributor.nonIdAuthorTashman, Katherine-
dc.contributor.nonIdAuthorToonen, Ruud F. G.-
dc.contributor.nonIdAuthorVerpelli, Chiara-
dc.contributor.nonIdAuthorReig-Viader, Rita-
dc.contributor.nonIdAuthorWatanabe, Kyoko-
dc.contributor.nonIdAuthorvan Weering, Jan-
dc.contributor.nonIdAuthorAchsel, Tilmann-
dc.contributor.nonIdAuthorAshrafi, Ghazaleh-
dc.contributor.nonIdAuthorAsi, Nimra-
dc.contributor.nonIdAuthorBrown, Tyler C.-
dc.contributor.nonIdAuthorDe Camilli, Pietro-
dc.contributor.nonIdAuthorFeuermann, Marc-
dc.contributor.nonIdAuthorFoulger, Rebecca E.-
dc.contributor.nonIdAuthorGaudet, Pascale-
dc.contributor.nonIdAuthorJoglekar, Anoushka-
dc.contributor.nonIdAuthorKanellopoulos, Alexandros-
dc.contributor.nonIdAuthorMalenka, Robert-
dc.contributor.nonIdAuthorNicoll, Roger A.-
dc.contributor.nonIdAuthorPulido, Camila-
dc.contributor.nonIdAuthorde Juan-Sanz, Jaime-
dc.contributor.nonIdAuthorSheng, Morgan-
dc.contributor.nonIdAuthorSudhof, Thomas C.-
dc.contributor.nonIdAuthorTilgner, Hagen U.-
dc.contributor.nonIdAuthorBagni, Claudia-
dc.contributor.nonIdAuthorBayes, Alex-
dc.contributor.nonIdAuthorBiederer, Thomas-
dc.contributor.nonIdAuthorBrose, Nils-
dc.contributor.nonIdAuthorChua, John Jia En-
dc.contributor.nonIdAuthorDieterich, Daniela C.-
dc.contributor.nonIdAuthorGundelfinger, Eckart D.-
dc.contributor.nonIdAuthorHoogenraad, Casper-
dc.contributor.nonIdAuthorHuganir, Richard L.-
dc.contributor.nonIdAuthorJahn, Reinhard-
dc.contributor.nonIdAuthorKaeser, Pascal S.-
dc.contributor.nonIdAuthorKreutz, Michael R.-
dc.contributor.nonIdAuthorMcPherson, Peter S.-
dc.contributor.nonIdAuthorNeale, Ben M.-
dc.contributor.nonIdAuthorO'Connor, Vincent-
dc.contributor.nonIdAuthorPosthuma, Danielle-
dc.contributor.nonIdAuthorRyan, Timothy A.-
dc.contributor.nonIdAuthorSala, Carlo-
dc.contributor.nonIdAuthorFeng, Guoping-
dc.contributor.nonIdAuthorHyman, Steven E.-
dc.contributor.nonIdAuthorThomas, Paul D.-
dc.contributor.nonIdAuthorSmit, August B.-
dc.contributor.nonIdAuthorVerhage, Matthijs-
dc.description.isOpenAccessN-
dc.type.journalArticleArticle-
dc.subject.keywordPlusGENOME-WIDE ASSOCIATION-
dc.subject.keywordPlusGENE ONTOLOGY-
dc.subject.keywordPlusPROTEOME-
dc.subject.keywordPlusREVEALS-
dc.subject.keywordPlusARCHITECTURE-
dc.subject.keywordPlusSYNAPTOSOMES-
dc.subject.keywordPlusCOMPONENTS-
dc.subject.keywordPlusPLASTICITY-
dc.subject.keywordPlusMUTATIONS-
dc.subject.keywordPlusPROTEINS-
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