Synergistic mechanisms of Sanghuang-Danshen phytochemicals on postprandial vascular dysfunction in healthy subjects: A network biology approach based on a clinical trial

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dc.contributor.authorLim, Yeniko
dc.contributor.authorHwang, Woo Changko
dc.contributor.authorKim, JiYeonko
dc.contributor.authorLee, Choong Hwanko
dc.contributor.authorKim, Yong-Jaeko
dc.contributor.authorLee, Doheonko
dc.contributor.authorKwon, Oranko
dc.date.accessioned2019-07-23T06:21:12Z-
dc.date.available2019-07-23T06:21:12Z-
dc.date.created2019-07-23-
dc.date.created2019-07-23-
dc.date.issued2019-07-
dc.identifier.citationSCIENTIFIC REPORTS, v.9-
dc.identifier.issn2045-2322-
dc.identifier.urihttp://hdl.handle.net/10203/263745-
dc.description.abstractWith the increased risk of cardiovascular disease, the use of botanicals for vascular endothelial dysfunction has intensified. Here, we explored the synergistic mechanisms of Sang huang-Danshen (SD) phytochemicals on the homeostatic protection against high-fat-induced vascular dysfunction in healthy subjects, using a network biology approach, based on a randomised crossover clinical trial. Seventeen differential markers identified in blood samples taken at 0, 3 and 6 h post-treatment, together with 12SD phytochemicals, were mapped onto the network platform, termed the context-oriented directed associations. The resulting vascular sub-networks illustrated associations between 10 phytochemicals with 32 targets implicated in 143 metabolic/signalling pathways. The three key events included adhesion molecule production (ellagic acid, fumaric acid and cryptotanshinone; VCAM-1, ICAM-1 and PLA2G2A; fatty acid metabolism), platelet activation (ellagic acid, protocatechuic acid and tanshinone IIA; VEGFA, APAF1 and ATF3; mTOR, p53, Rap1 and VEGF signalling pathways) and endothelial inflammation (all phytochemicals, except cryptotanshinone; 29 targets, including TP53 and CASP3; MAPK and PI3K-Akt signalling pathways, among others). Our collective findings demonstrate a potential of SD to protect unintended risks of vascular dysfunction in healthy subjects, providing a deeper understanding of the complicated synergistic mechanisms of signature phytochemicals in SD.-
dc.languageEnglish-
dc.publisherNATURE PUBLISHING GROUP-
dc.titleSynergistic mechanisms of Sanghuang-Danshen phytochemicals on postprandial vascular dysfunction in healthy subjects: A network biology approach based on a clinical trial-
dc.typeArticle-
dc.identifier.wosid000474230900026-
dc.identifier.scopusid2-s2.0-85068361433-
dc.type.rimsART-
dc.citation.volume9-
dc.citation.publicationnameSCIENTIFIC REPORTS-
dc.identifier.doi10.1038/s41598-019-46289-3-
dc.contributor.localauthorLee, Doheon-
dc.contributor.nonIdAuthorLim, Yeni-
dc.contributor.nonIdAuthorKim, JiYeon-
dc.contributor.nonIdAuthorLee, Choong Hwan-
dc.contributor.nonIdAuthorKim, Yong-Jae-
dc.contributor.nonIdAuthorKwon, Oran-
dc.description.isOpenAccessY-
dc.type.journalArticleArticle-
dc.subject.keywordPlusENDOTHELIAL DYSFUNCTION-
dc.subject.keywordPlusIN-VITRO-
dc.subject.keywordPlusACTIVATION-
dc.subject.keywordPlusEXPRESSION-
dc.subject.keywordPlusPLATELET-
dc.subject.keywordPlusFAT-
dc.subject.keywordPlusPROFILES-
dc.subject.keywordPlusRISK-
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