Evidence of Aberrant Immune Response by Endogenous Double-Stranded RNAs: Attack from Within

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Many innate immune response proteins recognize foreign nucleic acids from invading pathogens to initiate antiviral signaling. These proteins mostly rely on structural characteristics of the nucleic acids rather than their specific sequences to distinguish self and nonself. One feature utilized by RNA sensors is the extended stretch of double-stranded RNA (dsRNA) base pairs. However, the criteria for recognizing nonself dsRNAs are rather lenient, and hairpin structure of self-RNAs can also trigger an immune response. Consequently, aberrant activation of RNA sensors has been reported in numerous human diseases. Yet, in most cases, the activating antigens remain unknown. Recent studies have developed sequencing techniques tailored to specifically capture dsRNAs and identified that various noncoding elements in the nuclear and the mitochondrial genome can generate dsRNAs. Here, the identity of endogenous dsRNAs, their recognition by dsRNA sensors, and their implications in the pathogenesis of human diseases ranging from inflammatory to degenerative are presented.
Publisher
WILEY
Issue Date
2019-07
Language
English
Article Type
Review
Citation

BIOESSAYS, v.41, no.7

ISSN
0265-9247
DOI
10.1002/bies.201900023
URI
http://hdl.handle.net/10203/263292
Appears in Collection
CBE-Journal Papers(저널논문)
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