DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jang, Seongmin | ko |
dc.contributor.author | Kang, Chanshin | ko |
dc.contributor.author | Yang, Han-Sol | ko |
dc.contributor.author | Jung, Taeyang | ko |
dc.contributor.author | Hebert, Hans | ko |
dc.contributor.author | Chung, Ka Young | ko |
dc.contributor.author | Kim, Seung Joong | ko |
dc.contributor.author | Hohng, Sungchul | ko |
dc.contributor.author | Song, Ji-Joon | ko |
dc.date.accessioned | 2019-06-24T01:50:05Z | - |
dc.date.available | 2019-06-24T01:50:05Z | - |
dc.date.created | 2019-06-12 | - |
dc.date.created | 2019-06-12 | - |
dc.date.created | 2019-06-12 | - |
dc.date.created | 2019-06-12 | - |
dc.date.created | 2019-06-12 | - |
dc.date.issued | 2019-06 | - |
dc.identifier.citation | GENES & DEVELOPMENT, v.33, no.11-12, pp.620 - 625 | - |
dc.identifier.issn | 0890-9369 | - |
dc.identifier.uri | http://hdl.handle.net/10203/262794 | - |
dc.description.abstract | DOT1L is a histone H3 Lys79 methyltransferase whose activity is stimulated by histone H2B Lys120 ubiquitination, suggesting cross-talk between histone H3 methylation and H2B ubiquitination. Here, we present cryo-EM structures of DOT1L complexes with unmodified or H2B ubiquitinated nucleosomes, showing that DOT1L recognizes H2B ubiquitin and the H2A/H2B acidic patch through a C-terminal hydrophobic helix and an arginine anchor in DOT1L, respectively. Furthermore, the structures combined with single-molecule FRET experiments show that H2B ubiquitination enhances a noncatalytic function of the DOT1L-destabilizing nucleosome. These results establish the molecular basis of the cross-talk between H2B ubiquitination and H3 Lys79 methylation as well as nucleosome destabilization by DOT1L. | - |
dc.language | English | - |
dc.publisher | COLD SPRING HARBOR LAB PRESS | - |
dc.title | Structural basis of recognition and destabilization of the histone H2B ubiquitinated nucleosome by the DOT1L histone H3 Lys79 methyltransferase | - |
dc.type | Article | - |
dc.identifier.wosid | 000470071900003 | - |
dc.identifier.scopusid | 2-s2.0-85065786784 | - |
dc.type.rims | ART | - |
dc.citation.volume | 33 | - |
dc.citation.issue | 11-12 | - |
dc.citation.beginningpage | 620 | - |
dc.citation.endingpage | 625 | - |
dc.citation.publicationname | GENES & DEVELOPMENT | - |
dc.identifier.doi | 10.1101/gad.323790.118 | - |
dc.contributor.localauthor | Kim, Seung Joong | - |
dc.contributor.localauthor | Song, Ji-Joon | - |
dc.contributor.nonIdAuthor | Kang, Chanshin | - |
dc.contributor.nonIdAuthor | Yang, Han-Sol | - |
dc.contributor.nonIdAuthor | Jung, Taeyang | - |
dc.contributor.nonIdAuthor | Hebert, Hans | - |
dc.contributor.nonIdAuthor | Chung, Ka Young | - |
dc.contributor.nonIdAuthor | Hohng, Sungchul | - |
dc.description.isOpenAccess | Y | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | cryo-EM | - |
dc.subject.keywordAuthor | histone | - |
dc.subject.keywordAuthor | nucleosome | - |
dc.subject.keywordAuthor | methylation | - |
dc.subject.keywordAuthor | ubiquitin | - |
dc.subject.keywordPlus | CORE PARTICLE | - |
dc.subject.keywordPlus | OCTAMER | - |
dc.subject.keywordPlus | DOMAIN | - |
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