DC Field | Value | Language |
---|---|---|
dc.contributor.author | Cho, Yeonsoo | ko |
dc.contributor.author | Park, Haram | ko |
dc.contributor.author | Jung, Hwajin | ko |
dc.contributor.author | Kweon, Hanseul | ko |
dc.contributor.author | Kim, Seoyeong | ko |
dc.contributor.author | Lee, Soo Yeon | ko |
dc.contributor.author | Han, Hyemin | ko |
dc.contributor.author | Cho, Yisul | ko |
dc.contributor.author | Kim, Seyeon | ko |
dc.contributor.author | Sim, Woong Seob | ko |
dc.contributor.author | Kim, Jeongmin | ko |
dc.contributor.author | Bae, Yongchul | ko |
dc.contributor.author | Kim, Eunjoon | ko |
dc.date.accessioned | 2019-05-28T09:25:03Z | - |
dc.date.available | 2019-05-28T09:25:03Z | - |
dc.date.created | 2019-05-28 | - |
dc.date.created | 2019-05-28 | - |
dc.date.created | 2019-05-28 | - |
dc.date.issued | 2019-05 | - |
dc.identifier.citation | FRONTIERS IN MOLECULAR NEUROSCIENCE, v.12 | - |
dc.identifier.issn | 1662-5099 | - |
dc.identifier.uri | http://hdl.handle.net/10203/262221 | - |
dc.description.abstract | Netrin-G ligand-1 (NGL-1), also known as LRRC4C, is a postsynaptic densities (PSDs)-95-interacting postsynaptic adhesion molecule that interacts trans-synaptically with presynaptic netrin-G1. NGL-1 and its family member protein NGL-2 are thought to promote excitatory synapse development through largely non-overlapping neuronal pathways. While NGL-2 is critical for excitatory synapse development in specific dendritic segments of neurons in an input-specific manner, whether NGL-1 has similar functions is unclear. Here, we show that Lrrc4c deletion in male mice moderately suppresses excitatory synapse development and function, but surprisingly, does so in an input-independent manner. While NGL-1 is mainly detected in the stratum lacunosum moleculare (SLM) layer of the hippocampus relative to the stratum radiatum (SR) layer, NGL-1 deletion leads to decreases in the number of PSDs in both SLM and SR layers in the ventral hippocampus. In addition, both SLM and SR excitatory synapses display suppressed short-term synaptic plasticity in the ventral hippocampus. These morphological and functional changes are either absent or modest in the dorsal hippocampus. The input-independent synaptic changes induced by Lrrc4c deletion involve abnormal translocation of NGL-2 from the SR to SLM layer. These results suggest that Lrrc4c deletion moderately suppresses hippocampal excitatory synapse development and function in an input-independent manner. | - |
dc.language | English | - |
dc.publisher | FRONTIERS MEDIA SA | - |
dc.title | NGL-1/LRRC4C Deletion Moderately Suppresses Hippocampal Excitatory Synapse Development and Function in an Input-Independent Manner | - |
dc.type | Article | - |
dc.identifier.wosid | 000467993500001 | - |
dc.identifier.scopusid | 2-s2.0-85069497127 | - |
dc.type.rims | ART | - |
dc.citation.volume | 12 | - |
dc.citation.publicationname | FRONTIERS IN MOLECULAR NEUROSCIENCE | - |
dc.identifier.doi | 10.3389/fnmol.2019.00119 | - |
dc.contributor.localauthor | Kim, Eunjoon | - |
dc.contributor.nonIdAuthor | Cho, Yeonsoo | - |
dc.contributor.nonIdAuthor | Jung, Hwajin | - |
dc.contributor.nonIdAuthor | Han, Hyemin | - |
dc.contributor.nonIdAuthor | Cho, Yisul | - |
dc.contributor.nonIdAuthor | Kim, Seyeon | - |
dc.contributor.nonIdAuthor | Sim, Woong Seob | - |
dc.contributor.nonIdAuthor | Bae, Yongchul | - |
dc.description.isOpenAccess | Y | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | synapse | - |
dc.subject.keywordAuthor | trans-synaptic adhesion | - |
dc.subject.keywordAuthor | NGL-1 | - |
dc.subject.keywordAuthor | LRRC4C | - |
dc.subject.keywordAuthor | PSD-95 | - |
dc.subject.keywordAuthor | synaptic transmission | - |
dc.subject.keywordAuthor | synaptic plasticity | - |
dc.subject.keywordPlus | ADHESION MOLECULES | - |
dc.subject.keywordPlus | CORTICAL INPUT | - |
dc.subject.keywordPlus | PTP-SIGMA | - |
dc.subject.keywordPlus | CA1 | - |
dc.subject.keywordPlus | NETRIN | - |
dc.subject.keywordPlus | LAR | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | PLASTICITY | - |
dc.subject.keywordPlus | ORGANIZATION | - |
dc.subject.keywordPlus | NEUROLIGINS | - |
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