Synaptic Plasticity Controls Sensory Responses through Frequency-Dependent Gamma Oscillation Resonance

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Synchronized gamma frequency oscillations in neural networks are thought to be important to sensory information processing, and their effects have been intensively studied. Here we describe a mechanism by which the nervous system can readily control gamma oscillation effects, depending selectively on visual stimuli. Using a model neural network simulation, we found that sensory response in the primary visual cortex is significantly modulated by the resonance between "spontaneous'' and "stimulus-driven'' oscillations. This gamma resonance can be precisely controlled by the synaptic plasticity of thalamocortical connections, and cortical response is regulated differentially according to the resonance condition. The mechanism produces a selective synchronization between the afferent and downstream neural population. Our simulation results explain experimental observations such as stimulus-dependent synchronization between the thalamus and the cortex at different oscillation frequencies. The model generally shows how sensory information can be selectively routed depending on its frequency components.
Publisher
PUBLIC LIBRARY SCIENCE
Issue Date
2010-09
Language
English
Article Type
Article
Keywords

LATERAL GENICULATE-NUCLEUS; SHORT-TERM DEPRESSION; PRIMARY VISUAL-CORTEX; THALAMOCORTICAL SYNAPSES; IN-VIVO; SYNCHRONIZED OSCILLATIONS; NEURONAL SYNCHRONIZATION; INTERNEURON NETWORKS; THALAMIC INPUTS; SIMPLE CELLS

Citation

PLOS COMPUTATIONAL BIOLOGY, v.6, no.9

ISSN
1553-734X
DOI
10.1371/journal.pcbi.1000927
URI
http://hdl.handle.net/10203/261523
Appears in Collection
BiS-Journal Papers(저널논문)
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