Interactions between Host Immunity and Skin-Colonizing Staphylococci: No Two Siblings Are Alike

Cited 2 time in webofscience Cited 0 time in scopus
  • Hit : 136
  • Download : 7
As the outermost layer of the body, the skin harbors innumerable and varied microorganisms. These microorganisms interact with the host, and these interactions contribute to host immunity. One of the most abundant genera of skin commensals is Staphylococcus. Bacteria belonging to this genus are some of the most influential commensals that reside on the skin. For example, colonization by Staphylococcus aureus, a well-known pathogen, increases inflammatory responses within the skin. Conversely, colonization by Staphylococcus epidermis, a coagulase-negative staphylococcal species that are prevalent throughout the skin, can be innocuous or beneficial. Thus, manipulating the abundance of these two bacterial species likely alters the skin microbiome and modulates the cutaneous immune response, with potential implications for various inflammation-associated skin diseases. Importantly, before researchers can begin manipulating the skin microbiome to prevent and treat disease, they must first fully understand how these two species can modulate the cutaneous immune response. In this review, we discuss the nature of the interactions between these two bacterial species and immune cells within the skin, discussing their immunogenicity within the context of skin disorders.
Publisher
MDPI
Issue Date
2019-02
Language
English
Article Type
Review
Citation

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.20, no.3

ISSN
1422-0067
DOI
10.3390/ijms20030718
URI
http://hdl.handle.net/10203/261503
Appears in Collection
MSE-Journal Papers(저널논문)
Files in This Item
ijms-20-00718-v2.pdf(1.14 MB)Download
This item is cited by other documents in WoS
⊙ Detail Information in WoSⓡ Click to see webofscience_button
⊙ Cited 2 items in WoS Click to see citing articles in records_button

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0