Knee kinematics, cartilage morphology, and osteoarthritis after ACL injury

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This review examines a mechanism for the initiation of osteoarthritis after anterior cruciate ligament (ACL) injury by considering the relationship between reported ambulatory changes after ACL injury, cartilage adaptation to load, and the association between cartilage loads during walking and regional variations in cartilage structure and biology. Taken together, these observations suggest that cartilage degeneration after ACL injury could be caused by a kinematic gait change that shifts ambulatory loading applied to cartilage. Such a shift may cause regions of cartilage to become newly loaded, be subjected to altered levels of compression and tension, or become unloaded. The metabolic sensitivity of chondrocytes to such changes in their mechanical environment, combined with the low adaptation potential of mature cartilage, could lead to cartilage degeneration and premature ostcoarthritis after ACL injury. This proposed mechanism demonstrates the value of using the ACL injury model to understand the relationship between mechanics and biology, as well as helping to explain the importance of restoring normal ambulatory kinematics after ACL injury to avoid premature osteoarthritis.
Publisher
LIPPINCOTT WILLIAMS & WILKINS
Issue Date
2008-02
Language
English
Article Type
Article
Keywords

ANTERIOR CRUCIATE LIGAMENT; FLUID-INDUCED SHEAR; SPINAL-CORD-INJURY; YOUNG BEAGLE DOGS; ARTICULAR-CARTILAGE; WEIGHT-BEARING; TIBIOFEMORAL KINEMATICS; BIOCHEMICAL-CHANGES; HIGH PREVALENCE; TIBIAL PLATEAU

Citation

MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, v.40, no.2, pp.215 - 222

ISSN
0195-9131
DOI
10.1249/mss.0b013e31815cbb0e
URI
http://hdl.handle.net/10203/255650
Appears in Collection
ME-Journal Papers(저널논문)
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