DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Jung Hee | ko |
dc.contributor.author | Jung, Kyung Hee | ko |
dc.contributor.author | Kim, Soo Jung | ko |
dc.contributor.author | Yoon, Young-Chan | ko |
dc.contributor.author | Yan, Hong Hua | ko |
dc.contributor.author | Fang, Zhenghuan | ko |
dc.contributor.author | Lee, Ji Eun | ko |
dc.contributor.author | Lim, Joo Han | ko |
dc.contributor.author | Mah, Shinmee | ko |
dc.contributor.author | Hong, Sungwoo | ko |
dc.contributor.author | Kim, You-Sun | ko |
dc.contributor.author | Hong, Soon-Sun | ko |
dc.date.accessioned | 2019-03-19T01:06:01Z | - |
dc.date.available | 2019-03-19T01:06:01Z | - |
dc.date.created | 2019-02-18 | - |
dc.date.issued | 2019-01 | - |
dc.identifier.citation | CANCER LETTERS, v.444, pp.94 - 104 | - |
dc.identifier.issn | 0304-3835 | - |
dc.identifier.uri | http://hdl.handle.net/10203/251515 | - |
dc.description.abstract | Necroptosis is a form of regulated necrotic cell death mediated by receptor-interacting kinase 3 (RIP3). Recently, necroptosis has gained attention as a novel alternative therapy to target cancer cells. In this study, we screened several chemotherapeutics used in preclinical and clinical studies, and identified a drug HS-173 that induces RIP3-mediated necroptosis. HS-173 decreased the cell survival in a dose-dependent manner in RIP3-expressing lung cancer cells, compared to the cells lacking RIP3. Also, the cell death induced by HS-173 was rescued by specific necroptosis inhibitors such as necrostatin-1 and dabrafenib. Additionally, HS-173 increased the phosphorylation of RIP3 and MLKL, which was decreased by necroptosis inhibitors, indicating that HS-173 activates RIP3/MLKL signaling in lung cancer cells. HS-173 increased the necroptotic events, as observed by the increased levels of HMGB1 and necroptotic morphological features. Furthermore, HS-173 inhibited the tumor growth by stimulation of necroptosis in mouse xenograft models. Our findings offer new insights into the role of HS-173 in inducing necroptosis by enhancing RIP3 expression and activating the RIP3/MLKL signaling pathway in lung cancer cells. | - |
dc.language | English | - |
dc.publisher | ELSEVIER IRELAND LTD | - |
dc.title | HS-173 as a novel inducer of RIP3-dependent necroptosis in lung cancer | - |
dc.type | Article | - |
dc.identifier.wosid | 000457505400009 | - |
dc.identifier.scopusid | 2-s2.0-85059150046 | - |
dc.type.rims | ART | - |
dc.citation.volume | 444 | - |
dc.citation.beginningpage | 94 | - |
dc.citation.endingpage | 104 | - |
dc.citation.publicationname | CANCER LETTERS | - |
dc.identifier.doi | 10.1016/j.canlet.2018.12.006 | - |
dc.contributor.localauthor | Hong, Sungwoo | - |
dc.contributor.nonIdAuthor | Park, Jung Hee | - |
dc.contributor.nonIdAuthor | Jung, Kyung Hee | - |
dc.contributor.nonIdAuthor | Kim, Soo Jung | - |
dc.contributor.nonIdAuthor | Yoon, Young-Chan | - |
dc.contributor.nonIdAuthor | Yan, Hong Hua | - |
dc.contributor.nonIdAuthor | Fang, Zhenghuan | - |
dc.contributor.nonIdAuthor | Lee, Ji Eun | - |
dc.contributor.nonIdAuthor | Lim, Joo Han | - |
dc.contributor.nonIdAuthor | Kim, You-Sun | - |
dc.contributor.nonIdAuthor | Hong, Soon-Sun | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Necroptosis | - |
dc.subject.keywordAuthor | RIP3 | - |
dc.subject.keywordAuthor | MLKL | - |
dc.subject.keywordAuthor | Lung cancer | - |
dc.subject.keywordAuthor | HS-173 | - |
dc.subject.keywordPlus | MIXED LINEAGE KINASE | - |
dc.subject.keywordPlus | PI3K INHIBITOR | - |
dc.subject.keywordPlus | CELL-DEATH | - |
dc.subject.keywordPlus | ANTICANCER ACTIVITY | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | CHEMOTHERAPY | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordPlus | RIP3 | - |
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