Tumor Necrosis Factor and Regulatory T Cells

Cited 3 time in webofscience Cited 0 time in scopus
  • Hit : 151
  • Download : 3
CD4(+)CD25(+)FoxP3(+) regulatory T (Treg) cells play major roles in the maintenance of immune homeostasis. In this review, we comprehensively describe the relationship between tumor necrosis factor (TNF) and Treg cells, focusing on the effects of TNF on Treg cells and on TNF-producing Treg cells. Contradictory results have been reported for the effect of TNF on the suppressive activity of Treg cells. In patients with rheumatoid arthritis, TNF has been shown to reduce the suppressive activity of Treg cells. Meanwhile, however, TNF has also been reported to maintain the suppressive activity of Treg cells via a TNFR2-mediated mechanism. In addition, Treg cells have been found to acquire the ability to produce TNF under inflammatory conditions, such as acute viral hepatitis. These TNF-producing Treg cells exhibit T helper 17-like features and hold significance in various human diseases.
Publisher
YONSEI UNIV COLL MEDICINE
Issue Date
2019-02
Language
English
Article Type
Review
Citation

YONSEI MEDICAL JOURNAL, v.60, no.2, pp.126 - 131

ISSN
0513-5796
DOI
10.3349/ymj.2019.60.2.126
URI
http://hdl.handle.net/10203/250360
Appears in Collection
MSE-Journal Papers(저널논문)
Files in This Item
000456318500002.pdf(748.66 kB)Download
This item is cited by other documents in WoS
⊙ Detail Information in WoSⓡ Click to see webofscience_button
⊙ Cited 3 items in WoS Click to see citing articles in records_button

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0