Biosynthetically Inspired Transformation of Iboga to Monomeric Post-Iboga Alkaloids

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Organisms have evolved to produce various natural products from a common precursor as a means of maximizing the number of secondary metabolites, thus acquiring selectional advantages. By adopting nature's divergent biosynthetic strategy, we transformed (+)-catharanthine to various iboga and post-iboga alkaloids, including (-)-conodusine A, (+)-conodusines B and C, (-)-voatinggine, (-)-tabertinggine, and (+)-dippinine B. Well-orchestrated oxidations and reorganizations of catharanthine derivatives enabled chemical access to these natural products.
Publisher
CELL PRESS
Issue Date
2019-02
Language
English
Article Type
Article
Citation

CHEM, v.5, no.2, pp.353 - 363

ISSN
2451-9294
DOI
10.1016/j.chempr.2018.10.009
URI
http://hdl.handle.net/10203/250348
Appears in Collection
CH-Journal Papers(저널논문)
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