Applying Multivalent Biomolecular Interactions for Biosensors

Cited 2 time in webofscience Cited 0 time in scopus
  • Hit : 135
  • Download : 0
Multivalent interactions between more than one interconnected biomolecule are easily found in diverse natural systems. With the cooperation of many interacting pairs, this clustered binding can achieve highly enhanced affinities. Whereas the binding of an individual pair remains reversible, the binding between multivalent biomolecules can become nearly irreversible. Although the underlying principles of the multivalent effect have yet to be revealed, this intriguing concept of multivalent interaction has been widely applied to diverse fields. Multivalency has become a key strategy to increase the potency of inhibitors against target pathogens and, more recently, enhanced target binding by multivalency has offered an attractive strategy for biosensing. In this article, the current status of multivalent interaction studies and their progress in the biosensing area will be discussed.
Publisher
WILEY-V C H VERLAG GMBH
Issue Date
2018-12
Language
English
Article Type
Article
Citation

CHEMISTRY-A EUROPEAN JOURNAL, v.24, no.72, pp.19103 - 19109

ISSN
0947-6539
DOI
10.1002/chem.201801408
URI
http://hdl.handle.net/10203/249798
Appears in Collection
CH-Journal Papers(저널논문)
Files in This Item
There are no files associated with this item.
This item is cited by other documents in WoS
⊙ Detail Information in WoSⓡ Click to see webofscience_button
⊙ Cited 2 items in WoS Click to see citing articles in records_button

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0