Paper-Based Biochip Assays and Recent Developments: A Review

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Biomolecules in human body serve as biomarker for diagnosis of diseases, and paper-based biochips have become of much interest for development of biomolecule sensing. Cellulose micro-/nanofiber matrices consisting of paper allow not only capillary-driven flow without external pumping owing to abundant micro-/nanopores but also three-dimensional (3D) hierarchical micro-/nanostructures as 3D templates for microfluidic bioassays. Besides, colloidal and thermal evaporated metal nanoparticles on cellulose fibers offer huge opportunities in nanoplasmonic biosensing. Here, we review paper-based biochips including microfluidic paper-based assays and nanoplasmonic biosensors and further discuss micro-/nanofabrication of paper-based biochips and their applications in biomolecule detection. © 2018, The Korean BioChip Society and Springer-Verlag GmbH Germany, part of Springer Nature.
Publisher
KOREAN BIOCHIP SOCIETY-KBCS
Issue Date
2018-03
Language
English
Article Type
Review
Citation

BIOCHIP JOURNAL, v.12, no.1

ISSN
1976-0280
DOI
10.1007/s13206-017-2101-3
URI
http://hdl.handle.net/10203/248786
Appears in Collection
BiS-Journal Papers(저널논문)
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