DC Field | Value | Language |
---|---|---|
dc.contributor.author | Nam, J. | ko |
dc.contributor.author | Lee, Y. | ko |
dc.contributor.author | Yang, Y. | ko |
dc.contributor.author | Jeong, S. | ko |
dc.contributor.author | Kim, W. | ko |
dc.contributor.author | Yoo, J.-W. | ko |
dc.contributor.author | Moon, J.-O. | ko |
dc.contributor.author | Lee, C. | ko |
dc.contributor.author | Chung, H.Y. | ko |
dc.contributor.author | Kim, M.-S. | ko |
dc.contributor.author | Jon, Sangyong | ko |
dc.contributor.author | Jung, Y. | ko |
dc.date.accessioned | 2018-12-20T08:06:28Z | - |
dc.date.available | 2018-12-20T08:06:28Z | - |
dc.date.created | 2018-12-14 | - |
dc.date.created | 2018-12-14 | - |
dc.date.created | 2018-12-14 | - |
dc.date.created | 2018-12-14 | - |
dc.date.created | 2018-12-14 | - |
dc.date.issued | 2018-08 | - |
dc.identifier.citation | FREE RADICAL BIOLOGY AND MEDICINE, v.124, pp.232 - 240 | - |
dc.identifier.issn | 0891-5849 | - |
dc.identifier.uri | http://hdl.handle.net/10203/248769 | - |
dc.description.abstract | Bilirubin (BR) is generated by the reduction of biliverdin (BV), a metabolite that results from the catalytic degradation of heme by the isoforms of heme oxygenase (HO). BV is nontoxic and water-soluble but BR is potentially toxic and lipophilic. Therefore, a further metabolic step is required for BR before excretion is possible. The reductive conversion of BV to BR costs energy and is evolutionarily conserved in human physiology. There must be a compelling reason for this apparently nonsensical evolutionary conservation. In addition to the differences between BR and BV—such as water solubility, antioxidant activity, and participation as a receptor ligand—in the present study, we focused on the chemistry of the two metabolites with regard to an electrophilic functional group called a Michael reaction acceptor (MRA). Our data reveal that the BR reacts with thiol compounds forming adducts, whereas no reaction occurs with BV. Furthermore, the binding of biotin-tagged BR to Kelch-like ECH-associated protein 1 (KEAP1)—a biological electrophile sensor—was prevented by pretreatment with BR or a thiol compound, but was not by pretreatment with BV. In cells, BR could bind to KEAP1 to release and activate nuclear factor-erythroid 2 (NF-E2) p45-related factor 2, a cytoprotective transcription factor, leading to the induction of HO-1. These findings may provide a physiological rationale for the energy-consuming conversion of BV to BR. © 2018 | - |
dc.language | English | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.title | Is it worth expending energy to convert biliverdin into bilirubin? | - |
dc.type | Article | - |
dc.identifier.wosid | 000441516300022 | - |
dc.identifier.scopusid | 2-s2.0-85048841839 | - |
dc.type.rims | ART | - |
dc.citation.volume | 124 | - |
dc.citation.beginningpage | 232 | - |
dc.citation.endingpage | 240 | - |
dc.citation.publicationname | FREE RADICAL BIOLOGY AND MEDICINE | - |
dc.identifier.doi | 10.1016/j.freeradbiomed.2018.06.010 | - |
dc.contributor.localauthor | Jon, Sangyong | - |
dc.contributor.nonIdAuthor | Nam, J. | - |
dc.contributor.nonIdAuthor | Lee, Y. | - |
dc.contributor.nonIdAuthor | Yang, Y. | - |
dc.contributor.nonIdAuthor | Jeong, S. | - |
dc.contributor.nonIdAuthor | Kim, W. | - |
dc.contributor.nonIdAuthor | Yoo, J.-W. | - |
dc.contributor.nonIdAuthor | Moon, J.-O. | - |
dc.contributor.nonIdAuthor | Lee, C. | - |
dc.contributor.nonIdAuthor | Chung, H.Y. | - |
dc.contributor.nonIdAuthor | Kim, M.-S. | - |
dc.contributor.nonIdAuthor | Jung, Y. | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Bilirubin | - |
dc.subject.keywordAuthor | Biliverdin | - |
dc.subject.keywordAuthor | Michael reaction acceptor | - |
dc.subject.keywordAuthor | Electrophile | - |
dc.subject.keywordAuthor | Kelch-like ECH-associated protein 1 | - |
dc.subject.keywordAuthor | Nuclear factor-erythroid 2 (NF-E2) p45-related factor 2 | - |
dc.subject.keywordAuthor | Biliverdin reductase | - |
dc.subject.keywordPlus | HEME OXYGENASE | - |
dc.subject.keywordPlus | UNCONJUGATED BILIRUBIN | - |
dc.subject.keywordPlus | METABOLISM | - |
dc.subject.keywordPlus | REDUCTASE | - |
dc.subject.keywordPlus | GLUTATHIONE | - |
dc.subject.keywordPlus | PRODUCTS | - |
dc.subject.keywordPlus | INSIGHTS | - |
dc.subject.keywordPlus | INFANTS | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | HEALTH | - |
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