Stretchable, Implantable, Nanostructured Flow-Diverter System for Quantification of Intra-aneurysmal Hemodynamics

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dc.contributor.authorHowe, Connorko
dc.contributor.authorMishra, Saswatko
dc.contributor.authorKim, Yun-Soungko
dc.contributor.authorChen, Yanfeiko
dc.contributor.authorYe, Sang-Hoko
dc.contributor.authorWagner, William R.ko
dc.contributor.authorJeong, Jae-Woongko
dc.contributor.authorByun, Hun-Sooko
dc.contributor.authorKim, Jong-Hoonko
dc.contributor.authorChun, Youngjaeko
dc.contributor.authorYeo, Woon-Hongko
dc.date.accessioned2018-12-20T01:49:02Z-
dc.date.available2018-12-20T01:49:02Z-
dc.date.created2018-11-27-
dc.date.created2018-11-27-
dc.date.issued2018-08-
dc.identifier.citationACS NANO, v.12, no.8, pp.8706 - 8716-
dc.identifier.issn1936-0851-
dc.identifier.urihttp://hdl.handle.net/10203/247151-
dc.description.abstractRandom weakening of an intracranial blood vessel results in abnormal blood flow into an aneurysmal sac. Recent advancements show that an implantable flow diverter, integrated with a medical stent, enables a highly effective treatment of cerebral aneurysms by guiding blood flow into the normal vessel path. None of such treatment systems, however, offers post-treatment monitoring to assess the progress of sac occlusion. Therefore, physicians rely heavily on either angiography or magnetic resonance imaging. Both methods require a dedicated facility with sophisticated equipment settings and time-consuming, cumbersome procedures. In this paper, we introduce an implantable, stretchable, nanostructured flow-sensor system for quantification of intra-aneurysmal hemodynamics. The open-mesh membrane device is capable of effective implantation in complex neurovascular vessels with extreme stretchability (500% radial stretching) and bendability (180 with 0.75 mm radius of curvature) for monitoring of the treatment progress. A collection of quantitative mechanics, fluid dynamics, and experimental studies establish the fundamental aspects of design criteria for a highly compliant, implantable device. Hemocompatibility study using fresh ovine blood captures the device feasibility for long-term insertion in a blood vessel, showing less platelet deposition compared to that in existing implantable materials. In vitro demonstrations of three types of flow sensors show quantification of intra-aneurysmal blood flow in a pig aorta and the capability of observation of aneurysm treatment with a great sensitivity (detection limit as small as 0.032 m/s). Overall, this work describes a mechanically soft flow-diverter system that offers an effective treatment of aneurysms with an active monitoring of intra-aneurysmal hemodynamics.-
dc.languageEnglish-
dc.publisherAMER CHEMICAL SOC-
dc.subjectINTRACRANIAL ANEURYSMS-
dc.subjectCEREBRAL ANEURYSMS-
dc.subjectENDOVASCULAR TREATMENT-
dc.subjectEPIDERMAL ELECTRONICS-
dc.subjectSOFT ELECTRONICS-
dc.subjectMAGNESIUM ALLOY-
dc.subjectWIRELESS-
dc.subjectDEVICES-
dc.subjectDIVERSION-
dc.subjectNITINOL-
dc.titleStretchable, Implantable, Nanostructured Flow-Diverter System for Quantification of Intra-aneurysmal Hemodynamics-
dc.typeArticle-
dc.identifier.wosid000443525600124-
dc.identifier.scopusid2-s2.0-85050360136-
dc.type.rimsART-
dc.citation.volume12-
dc.citation.issue8-
dc.citation.beginningpage8706-
dc.citation.endingpage8716-
dc.citation.publicationnameACS NANO-
dc.identifier.doi10.1021/acsnano.8b04689-
dc.contributor.localauthorJeong, Jae-Woong-
dc.contributor.nonIdAuthorHowe, Connor-
dc.contributor.nonIdAuthorMishra, Saswat-
dc.contributor.nonIdAuthorKim, Yun-Soung-
dc.contributor.nonIdAuthorChen, Yanfei-
dc.contributor.nonIdAuthorYe, Sang-Ho-
dc.contributor.nonIdAuthorWagner, William R.-
dc.contributor.nonIdAuthorByun, Hun-Soo-
dc.contributor.nonIdAuthorKim, Jong-Hoon-
dc.contributor.nonIdAuthorChun, Youngjae-
dc.contributor.nonIdAuthorYeo, Woon-Hong-
dc.description.isOpenAccessN-
dc.type.journalArticleArticle-
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