DC Field | Value | Language |
---|---|---|
dc.contributor.author | Howe, Connor | ko |
dc.contributor.author | Mishra, Saswat | ko |
dc.contributor.author | Kim, Yun-Soung | ko |
dc.contributor.author | Chen, Yanfei | ko |
dc.contributor.author | Ye, Sang-Ho | ko |
dc.contributor.author | Wagner, William R. | ko |
dc.contributor.author | Jeong, Jae-Woong | ko |
dc.contributor.author | Byun, Hun-Soo | ko |
dc.contributor.author | Kim, Jong-Hoon | ko |
dc.contributor.author | Chun, Youngjae | ko |
dc.contributor.author | Yeo, Woon-Hong | ko |
dc.date.accessioned | 2018-12-20T01:49:02Z | - |
dc.date.available | 2018-12-20T01:49:02Z | - |
dc.date.created | 2018-11-27 | - |
dc.date.created | 2018-11-27 | - |
dc.date.created | 2018-11-27 | - |
dc.date.issued | 2018-08 | - |
dc.identifier.citation | ACS NANO, v.12, no.8, pp.8706 - 8716 | - |
dc.identifier.issn | 1936-0851 | - |
dc.identifier.uri | http://hdl.handle.net/10203/247151 | - |
dc.description.abstract | Random weakening of an intracranial blood vessel results in abnormal blood flow into an aneurysmal sac. Recent advancements show that an implantable flow diverter, integrated with a medical stent, enables a highly effective treatment of cerebral aneurysms by guiding blood flow into the normal vessel path. None of such treatment systems, however, offers post-treatment monitoring to assess the progress of sac occlusion. Therefore, physicians rely heavily on either angiography or magnetic resonance imaging. Both methods require a dedicated facility with sophisticated equipment settings and time-consuming, cumbersome procedures. In this paper, we introduce an implantable, stretchable, nanostructured flow-sensor system for quantification of intra-aneurysmal hemodynamics. The open-mesh membrane device is capable of effective implantation in complex neurovascular vessels with extreme stretchability (500% radial stretching) and bendability (180 with 0.75 mm radius of curvature) for monitoring of the treatment progress. A collection of quantitative mechanics, fluid dynamics, and experimental studies establish the fundamental aspects of design criteria for a highly compliant, implantable device. Hemocompatibility study using fresh ovine blood captures the device feasibility for long-term insertion in a blood vessel, showing less platelet deposition compared to that in existing implantable materials. In vitro demonstrations of three types of flow sensors show quantification of intra-aneurysmal blood flow in a pig aorta and the capability of observation of aneurysm treatment with a great sensitivity (detection limit as small as 0.032 m/s). Overall, this work describes a mechanically soft flow-diverter system that offers an effective treatment of aneurysms with an active monitoring of intra-aneurysmal hemodynamics. | - |
dc.language | English | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.subject | INTRACRANIAL ANEURYSMS | - |
dc.subject | CEREBRAL ANEURYSMS | - |
dc.subject | ENDOVASCULAR TREATMENT | - |
dc.subject | EPIDERMAL ELECTRONICS | - |
dc.subject | SOFT ELECTRONICS | - |
dc.subject | MAGNESIUM ALLOY | - |
dc.subject | WIRELESS | - |
dc.subject | DEVICES | - |
dc.subject | DIVERSION | - |
dc.subject | NITINOL | - |
dc.title | Stretchable, Implantable, Nanostructured Flow-Diverter System for Quantification of Intra-aneurysmal Hemodynamics | - |
dc.type | Article | - |
dc.identifier.wosid | 000443525600124 | - |
dc.identifier.scopusid | 2-s2.0-85050360136 | - |
dc.type.rims | ART | - |
dc.citation.volume | 12 | - |
dc.citation.issue | 8 | - |
dc.citation.beginningpage | 8706 | - |
dc.citation.endingpage | 8716 | - |
dc.citation.publicationname | ACS NANO | - |
dc.identifier.doi | 10.1021/acsnano.8b04689 | - |
dc.contributor.localauthor | Jeong, Jae-Woong | - |
dc.contributor.nonIdAuthor | Howe, Connor | - |
dc.contributor.nonIdAuthor | Mishra, Saswat | - |
dc.contributor.nonIdAuthor | Kim, Yun-Soung | - |
dc.contributor.nonIdAuthor | Chen, Yanfei | - |
dc.contributor.nonIdAuthor | Ye, Sang-Ho | - |
dc.contributor.nonIdAuthor | Wagner, William R. | - |
dc.contributor.nonIdAuthor | Byun, Hun-Soo | - |
dc.contributor.nonIdAuthor | Kim, Jong-Hoon | - |
dc.contributor.nonIdAuthor | Chun, Youngjae | - |
dc.contributor.nonIdAuthor | Yeo, Woon-Hong | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | intracranial aneurysm | - |
dc.subject.keywordAuthor | nanostructured sensor | - |
dc.subject.keywordAuthor | flow diverter | - |
dc.subject.keywordAuthor | implantable | - |
dc.subject.keywordAuthor | hemocompatible | - |
dc.subject.keywordAuthor | bioresorbable | - |
dc.subject.keywordPlus | INTRACRANIAL ANEURYSMS | - |
dc.subject.keywordPlus | CEREBRAL ANEURYSMS | - |
dc.subject.keywordPlus | ENDOVASCULAR TREATMENT | - |
dc.subject.keywordPlus | EPIDERMAL ELECTRONICS | - |
dc.subject.keywordPlus | SOFT ELECTRONICS | - |
dc.subject.keywordPlus | MAGNESIUM ALLOY | - |
dc.subject.keywordPlus | WIRELESS | - |
dc.subject.keywordPlus | DEVICES | - |
dc.subject.keywordPlus | DIVERSION | - |
dc.subject.keywordPlus | NITINOL | - |
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