Herpes Zoster DNA Vaccines with IL-7 and IL-33 Molecular Adjuvants Elicit Protective T Cell Immunity

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dc.contributor.authorKim, A. Reumko
dc.contributor.authorPark, Junsikko
dc.contributor.authorKim, Jong Hoonko
dc.contributor.authorKwak, Jeongeunko
dc.contributor.authorCho, Youngranko
dc.contributor.authorLee, Hyojinko
dc.contributor.authorJeong, Moonsupko
dc.contributor.authorPark, Su-Hyungko
dc.contributor.authorShin, Eui-Cheolko
dc.date.accessioned2018-11-22T07:08:09Z-
dc.date.available2018-11-22T07:08:09Z-
dc.date.created2018-11-19-
dc.date.created2018-11-19-
dc.date.created2018-11-19-
dc.date.issued2018-10-
dc.identifier.citationIMMUNE NETWORK, v.18, no.5-
dc.identifier.issn1598-2629-
dc.identifier.urihttp://hdl.handle.net/10203/246902-
dc.description.abstractHerpes zoster (HZ), or shingles, is caused by the reactivation of latent varicella-zoster virus (VZV) from the sensory ganglia when VZV-specific T-cell immunity is decreased because of aging or immunosuppression. In the present study, we developed HZ DNA vaccine candidates encoding VZV proteins and cytokine adjuvants, such as IL-7 and IL-33. We immunized C57BL/6 mice with DNA plasmids encoding VZV glycoprotein E (gE), immediate early (IE) 63, or IE62 proteins and found that robust VZV protein-specific T-cell responses were elicited by HZ DNA vaccination. Co-administration of DNA plasmids encoding IL-7 or IL-33 in HZ DNA vaccination significantly enhanced the magnitude of VZV proteinspecific T-cell responses. Protective immunity elicited by HZ DNA vaccination was proven by challenge experiments with a surrogate virus, vaccinia virus expressing gE (VV-gE). A single dose of HZ DNA vaccine strongly boosted gE-specific T-cell responses in mice with a history of previous infection by VV-gE. Thus, HZ DNA vaccines with IL-7 and IL-33 adjuvants strongly elicit protective immunity.-
dc.languageEnglish-
dc.publisherKOREA ASSOC IMMUNOLOGISTS-
dc.titleHerpes Zoster DNA Vaccines with IL-7 and IL-33 Molecular Adjuvants Elicit Protective T Cell Immunity-
dc.typeArticle-
dc.identifier.wosid000449229600006-
dc.identifier.scopusid2-s2.0-85059652953-
dc.type.rimsART-
dc.citation.volume18-
dc.citation.issue5-
dc.citation.publicationnameIMMUNE NETWORK-
dc.identifier.doi10.4110/in.2018.18.e38-
dc.identifier.kciidART002400671-
dc.contributor.localauthorPark, Su-Hyung-
dc.contributor.localauthorShin, Eui-Cheol-
dc.contributor.nonIdAuthorCho, Youngran-
dc.contributor.nonIdAuthorLee, Hyojin-
dc.contributor.nonIdAuthorJeong, Moonsup-
dc.description.isOpenAccessN-
dc.type.journalArticleArticle-
dc.subject.keywordAuthorHerpes zoster-
dc.subject.keywordAuthorT-cells-
dc.subject.keywordAuthorDNA vaccines-
dc.subject.keywordAuthorIL-7-
dc.subject.keywordAuthorIL-33-
dc.subject.keywordPlusHerpes zoster-
dc.subject.keywordPlusT-cells-
dc.subject.keywordPlusDNA vaccines-
dc.subject.keywordPlusIL-7-
dc.subject.keywordPlusIL-33-
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