Loss-of-function of IFT88 determines metabolic phenotypes in thyroid cancer

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dc.contributor.authorLee, Jungueeko
dc.contributor.authorYi, Shinaeko
dc.contributor.authorWon, Minhoko
dc.contributor.authorSong, Young Shinko
dc.contributor.authorYi, Hyon-Seungko
dc.contributor.authorPark, Young Jooko
dc.contributor.authorPark, Ki Cheolko
dc.contributor.authorKim, Jung Taeko
dc.contributor.authorChang, Joon Youngko
dc.contributor.authorLee, Min Joungko
dc.contributor.authorSul, Hae Joungko
dc.contributor.authorChoi, Ji Eunko
dc.contributor.authorKim, Koon Soonko
dc.contributor.authorKero, Jukkako
dc.contributor.authorKim, Joonko
dc.contributor.authorShong, Minhoko
dc.date.accessioned2018-09-18T05:51:33Z-
dc.date.available2018-09-18T05:51:33Z-
dc.date.created2018-08-27-
dc.date.created2018-08-27-
dc.date.issued2018-08-
dc.identifier.citationONCOGENE, v.37, no.32, pp.4455 - 4474-
dc.identifier.issn0950-9232-
dc.identifier.urihttp://hdl.handle.net/10203/245404-
dc.description.abstractPrimary cilia are microtubule-based, dynamic organelles characterized by continuous assembly and disassembly. The intraflagellar transport (IFT) machinery, including IFT88 in cilia, is involved in the maintenance of bidirectional motility along the axonemes, which is required for ciliogenesis and functional competence. Cancer cells are frequently associated with loss of primary cilia and IFT functions. However, there is little information on the role of IFT88 or primary cilia in the metabolic remodeling of cancer cells. Therefore, we investigated the cellular and metabolic effects of the loss-of-function (LOF) mutations of IFT88/primary cilia in thyroid cancer cells. IFT88-deficient 8505C thyroid cancer cells were generated using the CRISPR/Cas9 system, and RNA-sequencing analysis was performed. LOF of the IFT88 gene resulted in a marked defect in ciliogenesis and mitochondrial oxidative function. Gene expression patterns in IFT88-deficient thyroid cancer cells favored glycolysis and lipid biosynthesis. However, LOF of IFT88/primary cilia did not promote thyroid cancer cell proliferation, migration, and invasion. The results suggest that IFT88/primary mary cilia play a role in metabolic reprogramming in thyroid cancer cells.-
dc.languageEnglish-
dc.publisherNATURE PUBLISHING GROUP-
dc.subjectINTRAFLAGELLAR TRANSPORT PROTEINS-
dc.subjectCYSTIC KIDNEY-DISEASE-
dc.subjectBARDET-BIEDL-SYNDROME-
dc.subjectPRIMARY CILIA-
dc.subjectTUMOR SUPPRESSORS-
dc.subjectGENE TG737-
dc.subjectSENESCENCE-
dc.subjectCOMPLEX-
dc.subjectAURORA-
dc.subjectCELLS-
dc.titleLoss-of-function of IFT88 determines metabolic phenotypes in thyroid cancer-
dc.typeArticle-
dc.identifier.wosid000441144300009-
dc.identifier.scopusid2-s2.0-85046622906-
dc.type.rimsART-
dc.citation.volume37-
dc.citation.issue32-
dc.citation.beginningpage4455-
dc.citation.endingpage4474-
dc.citation.publicationnameONCOGENE-
dc.identifier.doi10.1038/s41388-018-0211-6-
dc.contributor.localauthorKim, Joon-
dc.contributor.nonIdAuthorLee, Junguee-
dc.contributor.nonIdAuthorYi, Shinae-
dc.contributor.nonIdAuthorWon, Minho-
dc.contributor.nonIdAuthorSong, Young Shin-
dc.contributor.nonIdAuthorYi, Hyon-Seung-
dc.contributor.nonIdAuthorPark, Young Joo-
dc.contributor.nonIdAuthorPark, Ki Cheol-
dc.contributor.nonIdAuthorKim, Jung Tae-
dc.contributor.nonIdAuthorChang, Joon Young-
dc.contributor.nonIdAuthorLee, Min Joung-
dc.contributor.nonIdAuthorSul, Hae Joung-
dc.contributor.nonIdAuthorChoi, Ji Eun-
dc.contributor.nonIdAuthorKim, Koon Soon-
dc.contributor.nonIdAuthorKero, Jukka-
dc.contributor.nonIdAuthorShong, Minho-
dc.description.isOpenAccessN-
dc.type.journalArticleArticle-
dc.subject.keywordPlusINTRAFLAGELLAR TRANSPORT PROTEINS-
dc.subject.keywordPlusCYSTIC KIDNEY-DISEASE-
dc.subject.keywordPlusBARDET-BIEDL-SYNDROME-
dc.subject.keywordPlusPRIMARY CILIA-
dc.subject.keywordPlusTUMOR SUPPRESSORS-
dc.subject.keywordPlusGENE TG737-
dc.subject.keywordPlusSENESCENCE-
dc.subject.keywordPlusCOMPLEX-
dc.subject.keywordPlusAURORA-
dc.subject.keywordPlusCELLS-
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