Structural Basis for LAR-RPTP-Mediated Synaptogenesis

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Leukocyte common antigen-related protein tyrosine phosphatases (LAR-RPTPs) are cellular receptors of heparan sulfate (HS) and chondroitin sulfate (CS) proteoglycans that regulate neurite outgrowth and neuronal regeneration. LAR-RPTPs have also received particular attention as the major presynaptic hubs for synapse organization through selective binding to numerous postsynaptic adhesion partners. Recent structural studies on LAR-RPTP-mediated trans-synaptic adhesion complexes have provided significant insight into the molecular basis of their specific interactions, the key codes for their selective binding, as well as the higher-order clustering of LAR-RPTPs necessary for synaptogenic activity. In this review, we summarize the structures of LAR-RPTPs in complex with various postsynaptic adhesion partners and discuss the molecular mechanisms underlying LAR-RPTP-mediated synaptogenesis.
Publisher
KOREAN SOC MOLECULAR & CELLULAR BIOLOGY
Issue Date
2018-07
Language
English
Article Type
Review
Keywords

PROTEIN-TYROSINE-PHOSPHATASES; SYNAPTIC ADHESION MOLECULES; RAT HIPPOCAMPAL-NEURONS; PTP-SIGMA; CRYSTAL-STRUCTURE; TRANSSYNAPTIC INTERACTION; INTERLEUKIN-1 RECEPTOR; MENTAL-RETARDATION; COMPLEX; FAMILY

Citation

MOLECULES AND CELLS, v.41, no.7, pp.622 - 630

ISSN
1016-8478
DOI
10.14348/molcells.2018.0202
URI
http://hdl.handle.net/10203/245200
Appears in Collection
MSE-Journal Papers(저널논문)
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