Total syntheses of spirocyclic PKS-NRPS-based fungal metabolites

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Since the first isolation of pseurotin A in 1976, over twenty five spirocyclic PKS-NRPS-based (polyketide synthase-nonribosomal peptide synthetase-based) fungal natural products have been discovered to date. The common 1-oxa-7-azaspiro[4.4]non-2-ene-4,6-dione core of this family of natural products has served as a platform for the development of novel chemistry and resulted in the development of numerous new reactivities and synthetic strategies. Herein, we delineate all reported syntheses of spirocyclic PKS-NRPS-based fungal metabolites including our own recent contributions on this subject. We showcase how a biosynthetic consideration could lead to concise synthetic routes to this family of natural products.
Publisher
ROYAL SOC CHEMISTRY
Issue Date
2018-05
Language
English
Article Type
Review
Keywords

ASYMMETRIC TOTAL-SYNTHESIS; PSEUDEUROTIUM-OVALIS STOLK; ENANTIOSELECTIVE MICHAEL ADDITIONS; PSEUROTIN-A; ABSOLUTE-CONFIGURATION; ASPERGILLUS-FUMIGATUS; STEREOCONTROLLED SYNTHESIS; BENZYLMAGNESIUM CHLORIDE; 1,3-DICARBONYL COMPOUNDS; ANGIOGENESIS INHIBITOR

Citation

CHEMICAL COMMUNICATIONS, v.54, no.50, pp.6750 - 6758

ISSN
1359-7345
DOI
10.1039/C8CC02315H
URI
http://hdl.handle.net/10203/244582
Appears in Collection
CH-Journal Papers(저널논문)
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