mTORC1 accelerates retinal development via the immunoproteasome

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dc.contributor.authorChoi, Ji Heonko
dc.contributor.authorJo, Hong-Seokko
dc.contributor.authorLim, Soyeonko
dc.contributor.authorKim, Hyoung Taiko
dc.contributor.authorLee, Kang Wooko
dc.contributor.authorMoon, Kyeong Hwanko
dc.contributor.authorHa, Tae Jeongko
dc.contributor.authorKwak, Sang-Sooko
dc.contributor.authorKim, Yehako
dc.contributor.authorLee, Eun-Jungko
dc.contributor.authorJoe, Cheol-Oko
dc.contributor.authorKim, Jin Wooko
dc.date.accessioned2018-07-24T02:59:10Z-
dc.date.available2018-07-24T02:59:10Z-
dc.date.created2018-07-16-
dc.date.created2018-07-16-
dc.date.created2018-07-16-
dc.date.issued2018-06-
dc.identifier.citationNATURE COMMUNICATIONS, v.9-
dc.identifier.issn2041-1723-
dc.identifier.urihttp://hdl.handle.net/10203/244563-
dc.description.abstractThe numbers and types of cells constituting vertebrate neural tissues are determined by cellular mechanisms that couple neurogenesis to the proliferation of neural progenitor cells. Here we identified a role of mammalian target of rapamycin complex 1 (mTORC1) in the development of neural tissue, showing that it accelerates progenitor cell cycle progression and neurogenesis in mTORC1-hyperactive tuberous sclerosis complex 1 (Tsc1)-deficient mouse retina. We also show that concomitant loss of immunoproteasome subunit Psmb9, which is induced by Stat1 (signal transducer and activator of transcription factor 1), decelerates cell cycle progression of Tsc1-deficient mouse retinal progenitor cells and normalizes retinal developmental schedule. Collectively, our results establish a developmental role for mTORC1, showing that it promotes neural development through activation of protein turnover via a mechanism involving the immunoproteasome.-
dc.languageEnglish-
dc.publisherNATURE PUBLISHING GROUP-
dc.subjectCELL-PROLIFERATION-
dc.subjectMAMMALIAN PROTEIN-
dc.subjectRAT RETINA-
dc.subjectRAPAMYCIN-
dc.subjectCOMPLEX-
dc.subjectDROSOPHILA-
dc.subjectGROWTH-
dc.subjectMICE-
dc.subjectGENE-
dc.subjectTRANSCRIPTION-
dc.titlemTORC1 accelerates retinal development via the immunoproteasome-
dc.typeArticle-
dc.identifier.wosid000436540700020-
dc.identifier.scopusid2-s2.0-85049132152-
dc.type.rimsART-
dc.citation.volume9-
dc.citation.publicationnameNATURE COMMUNICATIONS-
dc.identifier.doi10.1038/s41467-018-04774-9-
dc.contributor.localauthorJoe, Cheol-O-
dc.contributor.localauthorKim, Jin Woo-
dc.description.isOpenAccessY-
dc.type.journalArticleArticle-
dc.subject.keywordPlusCELL-PROLIFERATION-
dc.subject.keywordPlusMAMMALIAN PROTEIN-
dc.subject.keywordPlusRAT RETINA-
dc.subject.keywordPlusRAPAMYCIN-
dc.subject.keywordPlusCOMPLEX-
dc.subject.keywordPlusDROSOPHILA-
dc.subject.keywordPlusGROWTH-
dc.subject.keywordPlusMICE-
dc.subject.keywordPlusGENE-
dc.subject.keywordPlusTRANSCRIPTION-
dc.subject.keywordPlusCELL-PROLIFERATION-
dc.subject.keywordPlusMAMMALIAN PROTEIN-
dc.subject.keywordPlusRAT RETINA-
dc.subject.keywordPlusRAPAMYCIN-
dc.subject.keywordPlusCOMPLEX-
dc.subject.keywordPlusDROSOPHILA-
dc.subject.keywordPlusGROWTH-
dc.subject.keywordPlusMICE-
dc.subject.keywordPlusGENE-
dc.subject.keywordPlusTRANSCRIPTION-
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