DC Field | Value | Language |
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dc.contributor.advisor | Chang, Suk Bok | - |
dc.contributor.advisor | 장석복 | - |
dc.contributor.author | Jee, So Yeon | - |
dc.date.accessioned | 2018-06-20T06:26:23Z | - |
dc.date.available | 2018-06-20T06:26:23Z | - |
dc.date.issued | 2017 | - |
dc.identifier.uri | http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=718755&flag=dissertation | en_US |
dc.identifier.uri | http://hdl.handle.net/10203/243587 | - |
dc.description | 학위논문(석사) - 한국과학기술원 : 화학과, 2017.8,[ii, 41 p. :] | - |
dc.description.abstract | 1.Br$\o$nsted acid-mediated diastereoselective silyl-oxa-Prins cyclization Multisubstituted tetrahydropyranols is a versatile building block in organic synthesis because of their interesting biological activities. We developed an efficient synthetic route to tetrahydropyranols through diastereoselective silyl-oxa-Prins cyclization of α-silyloxy homoallylsilanes with various aldehydes mediated by Brønsted acids. Synthetically valuable tetrahydropyranol products were obtained in high yields with excellent diastereoselectivities. Both syn and anti diastereomers of tetrahydropyranols were selectively obtained by tuning the olefinic geometry of the homoallylsilane substrates. The procedure is operationally simple and large scale reaction was also smoothly performed under mild conditions. 2.(NHC)Cu-catalyzed Borylative Cross-coupling of Olefin and Aldehyde Functionalized organoboron compounds are useful building block utilized in synthesis of various functional molecules and medicines. We herein present the study of (NHC)Cu-catalyzed borylative cross coupling reaction of styrenic olefins and benzaldehydes. The Borylative cross-coupling were more efficient with the electron-deficient styrenes. However, rather limited substrate scope and poor diastereoselectivity have been revealed as the obvious challenges for the future development of this synthetically useful reaction. | - |
dc.language | eng | - |
dc.publisher | 한국과학기술원 | - |
dc.subject | diastereoselective Prins cyclization | - |
dc.subject | silyl-oxa-Prins cyclization | - |
dc.subject | tetrahydropyran | - |
dc.subject | tetrahydropyranol | - |
dc.subject | oxygen heterocycles▼aaldehydes▼aN-heterocyclic carbene▼acopper catalyst▼aborylative cross-coupling▼athree component reaction | - |
dc.subject | 부분 입체 선택적 프린스 고리화반응▼a실릴-옥사 프린스 고리화 반응▼a테트라하이드로피란▼a테트라하이드로피란올▼a산소 헤테로 고리▼aN-헤테로 사이클릭 카벤▼a구리 촉매▼a붕소화 짝지음 반응▼a3 성분 반응▼a알데하이드 | - |
dc.title | Search for the new reactivity of aldehydes | - |
dc.title.alternative | 알데하이드 반응성에 대한 연구 : 실릴-옥사-프린스 고리화 반응과 붕소화 짝지음 반응 | - |
dc.type | Thesis(Master) | - |
dc.identifier.CNRN | 325007 | - |
dc.description.department | 한국과학기술원 :화학과, | - |
dc.contributor.alternativeauthor | 지소연 | - |
dc.title.subtitle | Silyl-Oxa-Prins cyclization and borylative coupling reaction | - |
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