Neuronal calcium channel alpha(1) subunit interacts with AMPA receptor, increasing its cell surface localisation

Cited 2 time in webofscience Cited 0 time in scopus
  • Hit : 299
  • Download : 0
DC FieldValueLanguage
dc.contributor.authorSeo, Bo Amko
dc.contributor.authorLee, Jung-Hako
dc.contributor.authorKim, Ho Minko
dc.contributor.authorKang, Myoung-Gooko
dc.date.accessioned2018-05-24T02:25:00Z-
dc.date.available2018-05-24T02:25:00Z-
dc.date.created2018-05-08-
dc.date.created2018-05-08-
dc.date.created2018-05-08-
dc.date.issued2018-04-
dc.identifier.citationBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.498, no.3, pp.402 - 408-
dc.identifier.issn0006-291X-
dc.identifier.urihttp://hdl.handle.net/10203/242269-
dc.description.abstractVoltage-activated Ca2+ channels (Ca-v) play critical roles in excitable cells including neurons. Unlike the well-defined roles of Ca(v)2 for pre-synaptic neurotransmission, the post-synaptic function of Ca(v)2 is unclear. Based on our previous study demonstrating the postsynaptic association of the Ca(v)2 with the AMPA receptor (AMPA-R), in this study we sought to further analyse the Ca(v)2-AMPA-R association. We used a step-by-step dissociation of partially purified native Ca(v)2-AMPA-R complexes and co-immunoprecipitation of the Ca(v)2-AMPA-R complexes expressed in HEK293T cells to demonstrate that the main subunit of Ca-v, alpha(1), formed a complex with the AMPA-R without the auxiliary subunits beta, alpha(2)delta, gamma(2/3). The alpha(1) subunit increased the cell-surface localisation of the AMPA-R, which could be a post-synaptic function of the Ca(v)2. (C) 2018 Elsevier Inc. All rights reserved.-
dc.languageEnglish-
dc.publisherACADEMIC PRESS INC ELSEVIER SCIENCE-
dc.subjectGATED CA2+ CHANNELS-
dc.subjectGAMMA-SUBUNIT-
dc.subjectSTARGAZIN-
dc.subjectPHOSPHORYLATION-
dc.subjectEXPRESSION-
dc.subjectMEMBRANE-
dc.subjectBINDING-
dc.subjectPSD-95-
dc.subjectMOUSE-
dc.subjectSITE-
dc.titleNeuronal calcium channel alpha(1) subunit interacts with AMPA receptor, increasing its cell surface localisation-
dc.typeArticle-
dc.identifier.wosid000430640500005-
dc.identifier.scopusid2-s2.0-85042929370-
dc.type.rimsART-
dc.citation.volume498-
dc.citation.issue3-
dc.citation.beginningpage402-
dc.citation.endingpage408-
dc.citation.publicationnameBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS-
dc.identifier.doi10.1016/j.bbrc.2018.02.107-
dc.contributor.localauthorKim, Ho Min-
dc.contributor.nonIdAuthorLee, Jung-Ha-
dc.contributor.nonIdAuthorKang, Myoung-Goo-
dc.description.isOpenAccessN-
dc.type.journalArticleArticle-
dc.subject.keywordAuthorCalcium channel-
dc.subject.keywordAuthorGlutamate receptor-
dc.subject.keywordAuthorAMPA receptor-
dc.subject.keywordAuthorSynaptic plasticity-
dc.subject.keywordAuthorOn channel-
dc.subject.keywordAuthorCalcium channel subunit-
dc.subject.keywordPlusGATED CA2+ CHANNELS-
dc.subject.keywordPlusGAMMA-SUBUNIT-
dc.subject.keywordPlusSTARGAZIN-
dc.subject.keywordPlusPHOSPHORYLATION-
dc.subject.keywordPlusEXPRESSION-
dc.subject.keywordPlusMEMBRANE-
dc.subject.keywordPlusBINDING-
dc.subject.keywordPlusPSD-95-
dc.subject.keywordPlusMOUSE-
dc.subject.keywordPlusSITE-
Appears in Collection
MSE-Journal Papers(저널논문)
Files in This Item
There are no files associated with this item.
This item is cited by other documents in WoS
⊙ Detail Information in WoSⓡ Click to see webofscience_button
⊙ Cited 2 items in WoS Click to see citing articles in records_button

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0