Functional analysis of BC200 RNA in cancer cells. = 암 세포에서 BC200 RNA의 기능 분석에 관한 연구

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Noncoding DNA consists of 98% of whole human genome and more than 60% of them are consistently transcribed. Noncoding RNAs from that sequences delicately regulate gene expressions in cells. BC200 RNA is a noncoding RNA expressed in neuron cells where it controls local translational initiations. The BC200 RNA is not expressed in normal cells except for neurons, but it is abnormally expressed at several cancer cells. In this study, we analysed the functions of the BC200 RNA in cancer cells. The BC200 RNA promotes cellular motility by stabilizing S100A11 transcripts, which is highly related to cellular motility. We found that when BC200 knockdown were performed, HeLa cell motility was reduced and 29 gene-expressions were altered including the S100A11. We also observed that BC200 RNA was localized at p-bodies. The BC200 RNA seems to regulate specific genes in these granules. Together, our results show that BC200 RNA contributes to cancer developments by specifically regulating cancer-related genes in particular area.
Advisors
Lee, Younghoonresearcher이영훈researcher
Description
한국과학기술원 :화학과,
Publisher
한국과학기술원
Issue Date
2017
Identifier
325007
Language
eng
Description

학위논문(박사) - 한국과학기술원 : 화학과, 2017.2,[v, 86 p. :]

Keywords

BC200 RNA; Cancer; cellular motility; S100A11; p-body; 암; 세포이동성

URI
http://hdl.handle.net/10203/242145
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=675885&flag=dissertation
Appears in Collection
CH-Theses_Ph.D.(박사논문)
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