Fluorescent detection of nerve agent simulants = 모의 신경작용제 형광탐지 연구

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Chapter 2.2 Detection of nerve agent-related molecules based on BODIPY-salicylaldehyde oxime con-jugation was studied. Fluorescence intensity of the B-Sal-oxime species increases in the presence of diethyl cy-anophosphonate (DECP) whereas it decreases with of diethyl chlorophosphate (DCP) and diethyl methylphosphonate (DEMP). Benzonitrile formation in novel fluorescent B-sal-oxime system was elucidated using model substrates. Chapter 2.3 A new 1,8-naphthalimide fluorescent probe for the detection of diethyl cyanophosphonate, a very common nerve agent simulant, was synthesized and characterized fully. The probe showed ~50-fold en-hancement of fluorescence intensity over diethyl methylphosphonate. Importantly, the probe operates under aqueous conditions and neutral pH. The substitution reaction with the oxime group is fast; the resulting time-response of fluorescent enhancement was observed within ~30 s. It is also confirmed that the probe is able to detect diethyl cyanophosphonate in both gas and liquid phases through dual emissions available by silica plate assays. Chapter 3.1 A new fluorescent probe based on coumarin system for the detection of nerve agent simu-lants was developed. The probe showed the fluorescence enhancement with diethyl chlorophosphate over di-ethyl cyanophosphonate and diethyl methylphosphonate. This probe showed the fluorescence changes by in-tramolecular cyclization reaction. Chapter 3.2 Fluorescein as a reversible fluorescent sensor for nerve agent simulants diethyl chlorophos-phate (DCP), diethyl methylphosphonate (DEMP), and diethyl cyanophosphonate (DECP) was studied. Super-oxide allows for a “off-on” mechanism to regenerate fluorescein. The order of decrease in fluorescence inten-sity for nerve agents stimulants is DCP > DEMP >> DECP. Chapter 3.3 Chromogenic and fluorescent detection for nerve agents and simulants was studied with a meso-pyridyl-BODIPY system that showed selective chromogenic and fluorescent changes for Soman (GD) selectively. DFT calculations aided in determining the nature of the fluorescence “turn-off” signal and $\lambda_{abs,max} red-shifting$. Chapter 4.1 Two phenyl selenyl-based BODIPY turn-on fluorescent probes for detection of hypo-chlorous acid (HOCl) were synthesized whose emission intensity modulated by photo-induced electron transfer (PET) process. The probe 2 is intrinsically shows no background signal, however, after reaction with HOCl, oxidation of selenium foreclose PET process, which evoke a significant increase in fluorescence intensity. The fluorescence intensity of the probe 1 and 2 with HOCl shows a ~18 and ~50-fold fluorescent enhancement compared with that signal generated for other ROS.
Advisors
Churchill, David G.researcher처칠, 데이비드researcher
Description
한국과학기술원 :화학과,
Publisher
한국과학기술원
Issue Date
2016
Identifier
325007
Language
eng
Description

학위논문(박사) - 한국과학기술원 : 화학과, 2016.2,[ix, 166 p. :]

Keywords

fluorescence; nerve agents; DCP; DECP; BODIPY; coumarin; 1; 8-naphthalimide; oxime; HOCl; 화학작용제; 모의 신경작용제; 활성산소종; 형광탐지; 옥심

URI
http://hdl.handle.net/10203/242142
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=669297&flag=dissertation
Appears in Collection
CH-Theses_Ph.D.(박사논문)
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