DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | Oh, Byung-Ha | - |
dc.contributor.advisor | 오병하 | - |
dc.contributor.author | Sohn, Young-Sik | - |
dc.contributor.author | 손영식 | - |
dc.date.accessioned | 2018-05-23T19:34:48Z | - |
dc.date.available | 2018-05-23T19:34:48Z | - |
dc.date.issued | 2017 | - |
dc.identifier.uri | http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=675726&flag=dissertation | en_US |
dc.identifier.uri | http://hdl.handle.net/10203/241853 | - |
dc.description | 학위논문(박사) - 한국과학기술원 : 생명과학과, 2017.2,[vi, 56 p. :] | - |
dc.description.abstract | Legionella pneumophila is a human intracellular pathogen which encodes about 290 effector proteins, which are translocated into host cells through a secretion system. Only a few effector proteins have been shown to manipulate cellular processes during infection while the functional roles of the remaining majority are still unknown. Lpg0393 is an experimentally identified effector protein classified as a hypothetical protein. Through structural analysis using X-ray crystallography, I showed that Lpg0393 contains a Vps9-like domain which activates endosomal Rab proteins Rab5, Rab21 and Rab22. Consistently, Lpg0393 had a guanine-nucleotide exchange factor activity toward the Rab5 sub-cluster members. This study identifies the first case of a bacterial guanine-nucleotide exchange factor activating the endosomal Rab proteins, implying that the activation of these Rab proteins might be beneficial for the intracellular survival of Legionella pneumophila. | - |
dc.language | eng | - |
dc.publisher | 한국과학기술원 | - |
dc.subject | Legionella pneumopila | - |
dc.subject | bacterial effector | - |
dc.subject | Lpg0393 | - |
dc.subject | endosomal Rab proteins | - |
dc.subject | guanine-nucleotide exchange factor | - |
dc.subject | 레지오넬라 뉴모필라 | - |
dc.subject | 박테리아 이펙터 | - |
dc.subject | 엔도좀 Rab 단백질 | - |
dc.subject | 구아닌-뉴클레오타이드 교환 인자 | - |
dc.title | Structural and functional study of the Legionella pneumophila effector protein Lpg0393 | - |
dc.title.alternative | 레지오넬라 뉴모필라 이펙터 단백질 Lpg0393의 구조와 기능에 관한 연구 | - |
dc.type | Thesis(Ph.D) | - |
dc.identifier.CNRN | 325007 | - |
dc.description.department | 한국과학기술원 :생명과학과, | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.