DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Byoung Hyuck | ko |
dc.contributor.author | Jung, Heewon | ko |
dc.contributor.author | Seo, Seok Hyun | ko |
dc.contributor.author | Shin, Hyemi | ko |
dc.contributor.author | Kwon, Jeanny | ko |
dc.contributor.author | Suh, Jae Myoung | ko |
dc.date.accessioned | 2018-04-24T04:26:20Z | - |
dc.date.available | 2018-04-24T04:26:20Z | - |
dc.date.created | 2018-04-02 | - |
dc.date.created | 2018-04-02 | - |
dc.date.created | 2018-04-02 | - |
dc.date.created | 2018-04-02 | - |
dc.date.created | 2018-04-02 | - |
dc.date.issued | 2018-03 | - |
dc.identifier.citation | CELL DEATH & DISEASE, v.9 | - |
dc.identifier.issn | 2041-4889 | - |
dc.identifier.uri | http://hdl.handle.net/10203/241215 | - |
dc.description.abstract | Unwanted radiological or nuclear exposure remains a public health risk for which effective therapeutic countermeasures are lacking. Here, we evaluated the efficacy of fibroblast growth factor-2 (FGF2) in treating radiation-induced gastrointestinal syndrome (RIGS) incurred by lethal whole-body irradiation (WBI) when administered in conjunction with bone marrow transplantation (BMT). In vitro experiments indicated FGF2 treatment increased proliferation, reduced apoptosis, and upregulated AKT-GSK3 beta/beta-catenin signaling in irradiated IEC-6 cells. We next established and analyzed mice cohorts consisting of sham irradiation (Group Sh); 12 Gy WBI (Group A); WBI with BMT (Group B); WBI with FGF2 treatment (Group F); and WBI with BMT and FGF2 treatment (Group BF). At 2 weeks postirradiation, Group BF showed a dramatic increase in survival over all other groups. Intestinal epithelium of Group BF, but not Group B or F, showed augmented proliferation, decreased apoptosis, and preserved crypt numbers and morphology. Furthermore, Group BF maintained intestinal barrier function with minimal inflammatory disturbances in a manner comparable to Group Sh. In accordance, transcriptomic analyses showed significant upregulation of intestinal barrier and stem cell markers in Group BF relative to Groups A and B. Taken together, parenteral FGF2 synergizes with BMT to confer potent mitigation against RIGS. | - |
dc.language | English | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | Synergistic actions of FGF2 and bone marrow transplantation mitigate radiation-induced intestinal injury | - |
dc.type | Article | - |
dc.identifier.wosid | 000427426100013 | - |
dc.identifier.scopusid | 2-s2.0-85048278477 | - |
dc.type.rims | ART | - |
dc.citation.volume | 9 | - |
dc.citation.publicationname | CELL DEATH & DISEASE | - |
dc.identifier.doi | 10.1038/s41419-018-0421-4 | - |
dc.contributor.localauthor | Suh, Jae Myoung | - |
dc.contributor.nonIdAuthor | Kim, Byoung Hyuck | - |
dc.contributor.nonIdAuthor | Seo, Seok Hyun | - |
dc.contributor.nonIdAuthor | Kwon, Jeanny | - |
dc.description.isOpenAccess | Y | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | MESENCHYMAL STEM-CELLS | - |
dc.subject.keywordPlus | TOTAL-BODY IRRADIATION | - |
dc.subject.keywordPlus | GROWTH-FACTOR | - |
dc.subject.keywordPlus | IONIZING-RADIATION | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | SELF-RENEWAL | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | DAMAGE | - |
dc.subject.keywordPlus | MANAGEMENT | - |
dc.subject.keywordPlus | APOPTOSIS | - |
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