Synthesis, characterization of ZnO-chitosan nanocomposites and evaluation of its antifungal activity against pathogenic Candida albicans

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dc.contributor.authorDananjaya, S. H. S.ko
dc.contributor.authorKumar, R. Saravanako
dc.contributor.authorYang, Minyangko
dc.contributor.authorNikapitiya, Chamilaniko
dc.contributor.authorLee, Jeheeko
dc.contributor.authorZoysa, Mahanama Deko
dc.date.accessioned2018-03-23T00:14:41Z-
dc.date.available2018-03-23T00:14:41Z-
dc.date.created2018-03-20-
dc.date.created2018-03-20-
dc.date.issued2018-03-
dc.identifier.citationINTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, v.108, pp.1281 - 1288-
dc.identifier.issn0141-8130-
dc.identifier.urihttp://hdl.handle.net/10203/240925-
dc.description.abstractIn this study, we investigated the antifungal activity and cytotoxicity of ZnO-chitosan nanocomposites (ZnO-C NCs) against Candida albicans and human epithelial type 2 (HEp2) cells, respectively. The crystalline phase, morphology, composition, particle size and optical absorption properties of the synthesized ZnO-C NCs were systematically investigated by various contemporary methods. The X-ray diffraction analysis results showed characteristic diffraction peaks corresponding to both ZnO and chitosan, while field-emission scanning electron microscopy (FESEM) displayed clusters of spherical shaped particulate morphology. UV vis absorption spectra showed a shift in the optical absorption towards lower wavelength for ZnO-C NCs when compared to ZnO nanoparticles (NPs). The antifungal activity results (against C. albicans) showed that the minimum inhibitory concentration of ZnO NPs and ZnO-C NCs were 200 mu g/mL and 75 mu g/mL, respectively, suggesting the greater therapeutic potential of ZnO-C NCs. FESEM analysis results showed the substantial change in the external morphology of C. albicans after treatment with both ZnO NPs and ZnO-C NCs due to the fungal cell membrane damage. ZnO-C NCs displayed lower cytotoxicity with HEp2 cells indicating the good cytocompatibility of the synthesized ZnO-C NCs. It is expected that ZnO and chitosan complement each other and exhibit synergistic effects potential for antimicrobial and biomedical applications. (C) 2017 Elsevier B.V. All rights reserved.-
dc.languageEnglish-
dc.publisherELSEVIER SCIENCE BV-
dc.subjectGRAM-POSITIVE BACTERIA-
dc.subjectANTIBACTERIAL PROPERTIES-
dc.subjectNANOPARTICLES-
dc.subjectFILMS-
dc.subjectENHANCEMENT-
dc.subjectNANOWIRES-
dc.subjectNPS-
dc.titleSynthesis, characterization of ZnO-chitosan nanocomposites and evaluation of its antifungal activity against pathogenic Candida albicans-
dc.typeArticle-
dc.identifier.wosid000425071500146-
dc.identifier.scopusid2-s2.0-85033802668-
dc.type.rimsART-
dc.citation.volume108-
dc.citation.beginningpage1281-
dc.citation.endingpage1288-
dc.citation.publicationnameINTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES-
dc.identifier.doi10.1016/j.ijbiomac.2017.11.046-
dc.contributor.localauthorYang, Minyang-
dc.contributor.nonIdAuthorDananjaya, S. H. S.-
dc.contributor.nonIdAuthorKumar, R. Saravana-
dc.contributor.nonIdAuthorNikapitiya, Chamilani-
dc.contributor.nonIdAuthorLee, Jehee-
dc.contributor.nonIdAuthorZoysa, Mahanama De-
dc.description.isOpenAccessN-
dc.type.journalArticleArticle-
dc.subject.keywordAuthorZnO-
dc.subject.keywordAuthorChitosan-
dc.subject.keywordAuthorNanocomposites-
dc.subject.keywordAuthorAntifungal activity-
dc.subject.keywordAuthorCandida albicans-
dc.subject.keywordAuthorCytotoxicity-
dc.subject.keywordPlusGRAM-POSITIVE BACTERIA-
dc.subject.keywordPlusANTIBACTERIAL PROPERTIES-
dc.subject.keywordPlusNANOPARTICLES-
dc.subject.keywordPlusFILMS-
dc.subject.keywordPlusENHANCEMENT-
dc.subject.keywordPlusNANOWIRES-
dc.subject.keywordPlusNPS-
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