A novel hybrid of 6-chlorotacrine and metal-amyloid-beta modulator for inhibition of acetylcholinesterase and metal-induced amyloid-beta aggregation

Cited 50 time in webofscience Cited 0 time in scopus
  • Hit : 166
  • Download : 0
The number of people suffering from Alzheimer's disease (AD) is expected to increase dramatically in the coming decades. Currently, acetylcholinesterase inhibitors (AChEis) provide some relief of cognitive symptoms, while newer approaches, such as amyloid-beta (A beta)-targeted metal chelation, offer potential hope for slowing and/or reversing disease progression. This work details the synthesis and biochemical evaluation of a novel hybrid of 6-chlorotacrine and a metal-A beta modulator that chemically combines an AChEi and an A beta-targeted metal chelator into a single molecule. This hybrid shows potent inhibition of AChE under various conditions, interaction with Cu2+ and Zn2+, control of metal-free and metal-induced A beta aggregate assembly, and disaggregation of preformed metal-free and metal-associated A beta aggregates. As such, the hybrid described herein represents a promising, new multifunctional compound for AD studies.
Publisher
ROYAL SOC CHEMISTRY
Issue Date
2013-11
Language
English
Article Type
Article
Citation

CHEMICAL SCIENCE, v.4, no.11, pp.4137 - 4145

ISSN
2041-6520
DOI
10.1039/c3sc51902c
URI
http://hdl.handle.net/10203/240306
Appears in Collection
CH-Journal Papers(저널논문)
Files in This Item
There are no files associated with this item.
This item is cited by other documents in WoS
⊙ Detail Information in WoSⓡ Click to see webofscience_button
⊙ Cited 50 items in WoS Click to see citing articles in records_button

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0