Wireless Optofluidic Systems for Programmable In Vivo Pharmacology and Optogenetics

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In vivo pharmacology and optogenetics hold tremendous promise for dissection of neural circuits, cellular signaling, and manipulating neurophysiological systems in awake, behaving animals. Existing neural interface technologies, such as metal cannulas connected to external drug supplies for pharmacological infusions and tethered fiber optics for optogenetics, are not ideal for minimally invasive, un-tethered studies on freely behaving animals. Here, we introduce wireless optofluidic neural probes that combine ultrathin, soft microfluidic drug delivery with cellular-scale inorganic light-emitting diode (m-ILED) arrays. These probes are orders of magnitude smaller than cannulas and allow wireless, programmed spatiotemporal control of fluid delivery and photostimulation. We demonstrate these devices in freely moving animals to modify gene expression, deliver peptide ligands, and provide concurrent photostimulation with antagonist drug delivery to manipulate mesoaccumbens reward-related behavior. The minimally invasive operation of these probes forecasts utility in other organ systems and species, with potential for broad application in biomedical science, engineering, and medicine.
Publisher
CELL PRESS
Issue Date
2015-07
Language
English
Article Type
Article
Citation

CELL, v.162, no.3, pp.662 - 674

ISSN
0092-8674
DOI
10.1016/j.cell.2015.06.058
URI
http://hdl.handle.net/10203/238857
Appears in Collection
EE-Journal Papers(저널논문)
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