This study examines the effect of investment by universities on student entrepreneurial activities, with an emphasis on the mediating effect of educational support. The effectiveness of university support on students' entrepreneurial aspirations and motivations has long been of interest to researchers; however, the outcomes of previous studies are inconclusive. These studies mostly used survey data from a fraction of universities in a given country. To treat this topic more comprehensively, we empirically analyze how university support of entrepreneurial activities affects the number of student founders using a nationwide panel data set annually collected by a government agency in South Korea. Our findings suggest a significant and positive effect of university investment in entrepreneurship on the number of student founders. Differential mediating effects are observed according to the type of educational support. The results of this study may provide guidance in policy development for university and college educators in the form of a few recommendations for policymakers based on an understanding of the effectiveness of investments related to entrepreneurial activities.