Genes for synthesis of FR-008 polyketides에프알-008 폴리케타이드 합성에 관여하는 유전자

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The present invention relates to the base sequence of whole genes involved in the biosynthesis of FR-008 polyketides derived from Streptomyces sp. FR-008. This base sequence comprises genes coding for ketosynthase (KS), acyl transferase (AT), acyl carrier protein (ACP), ketoreductase (KR), dehydratase (DH) and enoyl reductase (ER) domains, and genes coding for modifier enzymes, such as ABC transporter, cytochrome P450 monooxygenase, ferredoxin, thioesterase, sugar synthetic protein, FAD-dependent monooxygenase, 4-amino-4-deoxychorismate (ADC) synthase and ADC lyase. The gene base sequence according to the present invention can be used to increase the productivity of the existing FR-008 polyketides or produce new FR-008 polyketides, through modification of its parts.
Assignee
KAIST
Country
US (United States)
Issue Date
2009-09-29
Application Date
2004-04-06
Application Number
10819386
Registration Date
2009-09-29
Registration Number
7595156
URI
http://hdl.handle.net/10203/232561
Appears in Collection
CBE-Patent(특허)
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