Water-soluble polypeptides comprised of repeat modules, method for preparing the same and method for a target-specific polypeptide and analysis of biological activity thereof인터날린 단백질의 N-말단 및 LRR 패밀리 단백질이 융합된 수용성 융합 폴리펩타이드 및 이의 제조 방법

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The present invention relates to a soluble polypeptide comprised of repeat modules. More particularly, the present invention relates to a soluble fusion polypeptide of the N-terminal domain of internalin and LRR (Leucine rich repeat) family protein, a method for preparing the polypeptide, a vector comprising a nucleic acid sequence encoding the polypeptide, a host cell comprising the vector, a method for producing a solubility and folding-improved fusion polypeptide by expressing the vector in the host cell, and a method for improving the solubility and folding of the fusion polypeptide. Further, the present invention relates to a method for preparing the polypeptide bound with a specific target and analyzing the efficacy of the soluble polypeptide.
Assignee
KAIST
Country
US (United States)
Issue Date
2016-09-13
Application Date
2012-03-22
Application Number
14005536
Registration Date
2016-09-13
Registration Number
9441017
URI
http://hdl.handle.net/10203/230443
Appears in Collection
BS-Patent(특허)BiS-Patent(특허)
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