Nanogap-Rich Au Nanowire SERS Sensor for Ultrasensitive Telomerase Activity Detection: Application to Gastric and Breast Cancer Tissues Diagnosis

Cited 39 time in webofscience Cited 0 time in scopus
  • Hit : 426
  • Download : 0
DC FieldValueLanguage
dc.contributor.authorEom, Gayoungko
dc.contributor.authorKim, Hongkiko
dc.contributor.authorHwang, Ahreumko
dc.contributor.authorSon, Hye-Youngko
dc.contributor.authorChoi, Yunako
dc.contributor.authorMoon, Jeongko
dc.contributor.authorKim, Donghyeongko
dc.contributor.authorLee, Miyeonko
dc.contributor.authorLim, Eun-Kyungko
dc.contributor.authorJeong, Jinyoungko
dc.contributor.authorHuh, Yong-Minko
dc.contributor.authorSeo, Min-Kyoko
dc.contributor.authorKang, Taejoonko
dc.contributor.authorKim, Bongsooko
dc.date.accessioned2017-11-08T05:46:36Z-
dc.date.available2017-11-08T05:46:36Z-
dc.date.created2017-10-23-
dc.date.created2017-10-23-
dc.date.issued2017-10-
dc.identifier.citationADVANCED FUNCTIONAL MATERIALS, v.27, no.37, pp.1701832-
dc.identifier.issn1616-301X-
dc.identifier.urihttp://hdl.handle.net/10203/226923-
dc.description.abstractTelomerase has attracted much attention as a universal cancer biomarker because telomerase is overexpressed in more than 85% of human cancer cells while suppressed in normal somatic cells. Since a strong association exists between telomerase activity and human cancers, the development of effective telomerase activity assay is critically important. Here, a nanogap-rich Au nanowire (NW) surface-enhanced Raman scattering (SERS) sensor is reported for detection of telomerase activity in various cancer cells and tissues. The nanogap-rich Au NWs are constructed by deposition of nano-particles on single-crystalline Au NWs and provided highly reproducible SERS spectra. The telomeric substrate (TS) primer-attached nanogap-rich Au NWs can detect telomerase activity through SERS measurement after the elongation of TS primers, folding into G-quadruplex structures, and intercalation of methylene blue. This sensor enables us to detect telomerase activity from various cancer cell lines with a detection limit of 0.2 cancer cells mL(-1). Importantly, the nanogap-rich Au NW sensor can diagnose gastric and breast cancer tissues accurately. The nanogap-rich Au NW sensors show strong SERS signals only in the presence of tumor tissues excised from 16 tumor-bearing mice, while negligible signals in the presence of heated tumor tissues or normal tissues. It is anticipated that nanogap-rich Au NW SERS sensors can be used for a universal cancer diagnosis and further biomedical applications including a diverse biomarker sensing.-
dc.languageEnglish-
dc.publisherWILEY-V C H VERLAG GMBH-
dc.subjectENHANCED RAMAN-SCATTERING-
dc.subjectNANOPILLAR ARRAYS-
dc.subjectLABEL-FREE-
dc.subjectPLASMONIC RESONANCES-
dc.subjectCATALYTIC SUBUNIT-
dc.subjectINTERSTICE SENSOR-
dc.subjectMETHYLENE-BLUE-
dc.subjectDNA-
dc.subjectNANOPARTICLES-
dc.subjectHYBRIDIZATION-
dc.titleNanogap-Rich Au Nanowire SERS Sensor for Ultrasensitive Telomerase Activity Detection: Application to Gastric and Breast Cancer Tissues Diagnosis-
dc.typeArticle-
dc.identifier.wosid000412324200004-
dc.identifier.scopusid2-s2.0-85026666862-
dc.type.rimsART-
dc.citation.volume27-
dc.citation.issue37-
dc.citation.beginningpage1701832-
dc.citation.publicationnameADVANCED FUNCTIONAL MATERIALS-
dc.identifier.doi10.1002/adfm.201701832-
dc.contributor.localauthorSeo, Min-Kyo-
dc.contributor.localauthorKim, Bongsoo-
dc.contributor.nonIdAuthorKim, Hongki-
dc.contributor.nonIdAuthorSon, Hye-Young-
dc.contributor.nonIdAuthorChoi, Yuna-
dc.contributor.nonIdAuthorMoon, Jeong-
dc.contributor.nonIdAuthorLim, Eun-Kyung-
dc.contributor.nonIdAuthorJeong, Jinyoung-
dc.contributor.nonIdAuthorHuh, Yong-Min-
dc.contributor.nonIdAuthorKang, Taejoon-
dc.description.isOpenAccessN-
dc.type.journalArticleArticle-
dc.subject.keywordAuthorgold nanowires-
dc.subject.keywordAuthornanogaps-
dc.subject.keywordAuthorsensors-
dc.subject.keywordAuthorsurface-enhanced Raman scattering-
dc.subject.keywordAuthortelomerase activity-
dc.subject.keywordPlusENHANCED RAMAN-SCATTERING-
dc.subject.keywordPlusNANOPILLAR ARRAYS-
dc.subject.keywordPlusLABEL-FREE-
dc.subject.keywordPlusPLASMONIC RESONANCES-
dc.subject.keywordPlusCATALYTIC SUBUNIT-
dc.subject.keywordPlusINTERSTICE SENSOR-
dc.subject.keywordPlusMETHYLENE-BLUE-
dc.subject.keywordPlusDNA-
dc.subject.keywordPlusNANOPARTICLES-
dc.subject.keywordPlusHYBRIDIZATION-
Appears in Collection
PH-Journal Papers(저널논문)CH-Journal Papers(저널논문)
Files in This Item
There are no files associated with this item.
This item is cited by other documents in WoS
⊙ Detail Information in WoSⓡ Click to see webofscience_button
⊙ Cited 39 items in WoS Click to see citing articles in records_button

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0